Spontaneous improvement of subacute exacerbation in a case of sensory ataxic neuropathy associated with Sjögren's syndrome

Kenji Maruyama, Yasushi Oya, Hiroshi Shigeto, Masafumi Ogawa, Mitsuru Kawai

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

We reported a 66-year-old man with Sjögren's syndrome (sicca syndrome) presenting a sensory ataxic neuropathy, which showed spontaneous remission. He developed difficulty in standing and walking during recent several months. Neurological examinations showed sensory ataxia with areflexia in all extremities and mild distal-dominant decrease in the superficial sensation. Laboratory examinations of blood, urine, and cerebrospinal fluid were all unremarkable; the blood levels of vitamin B1, B2, B6 and B12 were low normal. Sensory nerve action potentials and somatosensory evoked potentials were absent. Cervical cord MRI revealed no abnormal signals. Severe loss of myelinated fibers and scattered myelin ovoids were seen in sural nerve biopsy. Tentative diagnosis at admission was subacute sensory neuropathy associated with malignancy. Screening examinations for malignancy were undertaken and all revealed negative. Because of coexisting sicca symptoms and positive Shirmer test (0 mm), a lip biopsy was performed and a diagnosis of Sjögren's syndrome was confirmed. Sensory ataxia improved gradually. Two years later, blood B1 levels were low but he remained able to walk. This case is an uncommon example of spontaneous symptomatic remission in sensory ataxic neuropathy associated with Sjögren's syndrome.

元の言語英語
ページ(範囲)617-620
ページ数4
ジャーナルClinical Neurology
41
発行部数9
出版物ステータス出版済み - 12 1 2001
外部発表Yes

Fingerprint

Spontaneous Remission
Ataxia
Biopsy
Sural Nerve
Somatosensory Evoked Potentials
Riboflavin
Thiamine
Sjogren's Syndrome
Neurologic Examination
Vitamin B 12
Myelin Sheath
Lip
Action Potentials
Walking
Cerebrospinal Fluid
Neoplasms
Extremities
Urine
Cervical Cord

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

これを引用

Spontaneous improvement of subacute exacerbation in a case of sensory ataxic neuropathy associated with Sjögren's syndrome. / Maruyama, Kenji; Oya, Yasushi; Shigeto, Hiroshi; Ogawa, Masafumi; Kawai, Mitsuru.

:: Clinical Neurology, 巻 41, 番号 9, 01.12.2001, p. 617-620.

研究成果: ジャーナルへの寄稿記事

Maruyama, Kenji ; Oya, Yasushi ; Shigeto, Hiroshi ; Ogawa, Masafumi ; Kawai, Mitsuru. / Spontaneous improvement of subacute exacerbation in a case of sensory ataxic neuropathy associated with Sjögren's syndrome. :: Clinical Neurology. 2001 ; 巻 41, 番号 9. pp. 617-620.
@article{d7024ce287d34a3f9933ee3ef0c13833,
title = "Spontaneous improvement of subacute exacerbation in a case of sensory ataxic neuropathy associated with Sj{\"o}gren's syndrome",
abstract = "We reported a 66-year-old man with Sj{\"o}gren's syndrome (sicca syndrome) presenting a sensory ataxic neuropathy, which showed spontaneous remission. He developed difficulty in standing and walking during recent several months. Neurological examinations showed sensory ataxia with areflexia in all extremities and mild distal-dominant decrease in the superficial sensation. Laboratory examinations of blood, urine, and cerebrospinal fluid were all unremarkable; the blood levels of vitamin B1, B2, B6 and B12 were low normal. Sensory nerve action potentials and somatosensory evoked potentials were absent. Cervical cord MRI revealed no abnormal signals. Severe loss of myelinated fibers and scattered myelin ovoids were seen in sural nerve biopsy. Tentative diagnosis at admission was subacute sensory neuropathy associated with malignancy. Screening examinations for malignancy were undertaken and all revealed negative. Because of coexisting sicca symptoms and positive Shirmer test (0 mm), a lip biopsy was performed and a diagnosis of Sj{\"o}gren's syndrome was confirmed. Sensory ataxia improved gradually. Two years later, blood B1 levels were low but he remained able to walk. This case is an uncommon example of spontaneous symptomatic remission in sensory ataxic neuropathy associated with Sj{\"o}gren's syndrome.",
author = "Kenji Maruyama and Yasushi Oya and Hiroshi Shigeto and Masafumi Ogawa and Mitsuru Kawai",
year = "2001",
month = "12",
day = "1",
language = "English",
volume = "41",
pages = "617--620",
journal = "Clinical Neurology",
issn = "0009-918X",
publisher = "Societas Neurologica Japonica",
number = "9",

}

TY - JOUR

T1 - Spontaneous improvement of subacute exacerbation in a case of sensory ataxic neuropathy associated with Sjögren's syndrome

AU - Maruyama, Kenji

AU - Oya, Yasushi

AU - Shigeto, Hiroshi

AU - Ogawa, Masafumi

AU - Kawai, Mitsuru

PY - 2001/12/1

Y1 - 2001/12/1

N2 - We reported a 66-year-old man with Sjögren's syndrome (sicca syndrome) presenting a sensory ataxic neuropathy, which showed spontaneous remission. He developed difficulty in standing and walking during recent several months. Neurological examinations showed sensory ataxia with areflexia in all extremities and mild distal-dominant decrease in the superficial sensation. Laboratory examinations of blood, urine, and cerebrospinal fluid were all unremarkable; the blood levels of vitamin B1, B2, B6 and B12 were low normal. Sensory nerve action potentials and somatosensory evoked potentials were absent. Cervical cord MRI revealed no abnormal signals. Severe loss of myelinated fibers and scattered myelin ovoids were seen in sural nerve biopsy. Tentative diagnosis at admission was subacute sensory neuropathy associated with malignancy. Screening examinations for malignancy were undertaken and all revealed negative. Because of coexisting sicca symptoms and positive Shirmer test (0 mm), a lip biopsy was performed and a diagnosis of Sjögren's syndrome was confirmed. Sensory ataxia improved gradually. Two years later, blood B1 levels were low but he remained able to walk. This case is an uncommon example of spontaneous symptomatic remission in sensory ataxic neuropathy associated with Sjögren's syndrome.

AB - We reported a 66-year-old man with Sjögren's syndrome (sicca syndrome) presenting a sensory ataxic neuropathy, which showed spontaneous remission. He developed difficulty in standing and walking during recent several months. Neurological examinations showed sensory ataxia with areflexia in all extremities and mild distal-dominant decrease in the superficial sensation. Laboratory examinations of blood, urine, and cerebrospinal fluid were all unremarkable; the blood levels of vitamin B1, B2, B6 and B12 were low normal. Sensory nerve action potentials and somatosensory evoked potentials were absent. Cervical cord MRI revealed no abnormal signals. Severe loss of myelinated fibers and scattered myelin ovoids were seen in sural nerve biopsy. Tentative diagnosis at admission was subacute sensory neuropathy associated with malignancy. Screening examinations for malignancy were undertaken and all revealed negative. Because of coexisting sicca symptoms and positive Shirmer test (0 mm), a lip biopsy was performed and a diagnosis of Sjögren's syndrome was confirmed. Sensory ataxia improved gradually. Two years later, blood B1 levels were low but he remained able to walk. This case is an uncommon example of spontaneous symptomatic remission in sensory ataxic neuropathy associated with Sjögren's syndrome.

UR - http://www.scopus.com/inward/record.url?scp=0035740040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035740040&partnerID=8YFLogxK

M3 - Article

C2 - 11968748

AN - SCOPUS:0035740040

VL - 41

SP - 617

EP - 620

JO - Clinical Neurology

JF - Clinical Neurology

SN - 0009-918X

IS - 9

ER -