Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation

Jian Zhou, Shiqiao Ye, Toshifumi Fujiwara, Stavros C. Manolagas, Haibo Zhao

研究成果: Contribution to journalArticle査読

51 被引用数 (Scopus)

抄録

Background: Iron uptake through the transferrin-dependent pathway is essential for osteoclast differentiation. Results: Knocking down the expression of Steap4, an endosomal ferrireductase, inhibits osteoclast formation and decreases cellular iron and ROS production. Conclusion: Steap4 regulates cellular iron metabolism during osteoclast differentiation. Significance: This work provides new insights into the molecular mechanisms regulating cellular iron metabolism in osteoclast lineage cells.

本文言語英語
ページ(範囲)30064-30074
ページ数11
ジャーナルJournal of Biological Chemistry
288
42
DOI
出版ステータス出版済み - 10 18 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 細胞生物学

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