Stereocontrolled and convergent entry to CF2-sialosides: Synthesis of CF2-linked ganglioside GM4

Go Hirai, Toru Watanabe, Kazunori Yamaguchi, Taeko Miyagi, Mikiko Sodeoka

研究成果: Contribution to journalArticle査読

53 被引用数 (Scopus)

抄録

Sialidase-resistant ganglioside analogues having biological activities similar to those of natural gangliosides are expected to be important probes for clarifying the biological functions of gangliosides. Focusing on difluoromethylene-linked (CF2-linked) α(2,3)sialylgalactose as a core structure of sialidase-resistant ganglioside mimics, we have developed novel, stereocontrolled, and efficient methodologies to synthesize CF2-sialosides based on Ireland-Claisen rearrangement. CF2-linked α(2,3)sialylgalactose and CF2-linked GM4 were synthesized.

本文言語英語
ページ(範囲)15420-15421
ページ数2
ジャーナルJournal of the American Chemical Society
129
50
DOI
出版ステータス出版済み - 12 19 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

フィンガープリント

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