Stereoselective esterification of halogen-containing carboxylic acids by lipase in organic solvent: effects of alcohol chain length

Shi Hao Pan, Takuo Kawamoto, Toshiaki Fukui, Kenji Sonomoto, Atsuo Tanaka

研究成果: Contribution to journalArticle査読

44 被引用数 (Scopus)

抄録

Optical resolution of racemic carboxylic acids containing a halogen atom was attempted with stereoselective esterificatiob by Celite-adsorbed hydrolases in organic solvents. As lipase OF 360 from Candida cylindracea was found to stereoselectively esterify 2-(4-chlorophenoxy)propanoic acid, the (R)-enantiomer (d-isomer) of which is an important herbicide, the effects of alcohol chain length on stereoselectivity as well as reaction rate were investigated. The results revealed that the alcohol chain length markedly affected the stereoselective esterification of 2-(4-chlorophenoxy)propanoic acid: longer-chain alcohols, such as tetradecanol, served as excellent substrates for optical resolution of the acid, although the reaction rate was moderate.

本文言語英語
ページ(範囲)47-51
ページ数5
ジャーナルApplied Microbiology and Biotechnology
34
1
DOI
出版ステータス出版済み - 10 1 1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 応用微生物学とバイオテクノロジー

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