TY - JOUR
T1 - Steroid 5α-reductase inhibitory activity of condensed tannins from woody plants
AU - Liu, Jie
AU - Ando, Ryo
AU - Shimizu, Kuniyoshi
AU - Hashida, Koh
AU - Makino, Rei
AU - Ohara, Seiji
AU - Kondo, Ryuichiro
N1 - Funding Information:
Acknowledgments This work was supported in part by a Grant-in-Aid from the Emachu Research Fund (Tokyo, Japan), and by a Grant-in-Aid for Scientific Research (17658079) from the Japan Society for the Promotion of Science.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/1
Y1 - 2008/1
N2 - In humans, steroid 5α-reductase is involved in the development of benign prostatic hyperplasia (BPH). We tested the steroid 5α-reductase inhibitory activity of the 70% acetone extract of woody plants. The tannin polymer prepared from the 70% acetone extract showed the highest steroid 5α-reductase inhibitory activity. Furthermore, the steroid 5α-reductase inhibitory activity of tannins was not affected by the addition of superoxide dismutase or catalase. It was concluded that the steroid 5α-reductase inhibitory activity of condensed tannin was caused by binding to the steroid 5α-reductase, rather than from the peroxide/superoxide produced by tannins. The tannins, prepared from tree barks, with potential for steroid 5α-reductase inhibitory activity might be advantageous in therapy for steroid 5α-reductase diseases such as BPH or prostate cancer.
AB - In humans, steroid 5α-reductase is involved in the development of benign prostatic hyperplasia (BPH). We tested the steroid 5α-reductase inhibitory activity of the 70% acetone extract of woody plants. The tannin polymer prepared from the 70% acetone extract showed the highest steroid 5α-reductase inhibitory activity. Furthermore, the steroid 5α-reductase inhibitory activity of tannins was not affected by the addition of superoxide dismutase or catalase. It was concluded that the steroid 5α-reductase inhibitory activity of condensed tannin was caused by binding to the steroid 5α-reductase, rather than from the peroxide/superoxide produced by tannins. The tannins, prepared from tree barks, with potential for steroid 5α-reductase inhibitory activity might be advantageous in therapy for steroid 5α-reductase diseases such as BPH or prostate cancer.
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U2 - 10.1007/s10086-007-0905-9
DO - 10.1007/s10086-007-0905-9
M3 - Article
AN - SCOPUS:39749128705
SN - 1435-0211
VL - 54
SP - 68
EP - 75
JO - Journal of Wood Science
JF - Journal of Wood Science
IS - 1
ER -
