Steroidal saponins from dioscorea preussii

Turibio Kuiate Tabopda, Anne Claire Mitaine-Offer, Chiaki Tanaka, Tomofumi Miyamoto, Jean François Mirjolet, Olivier Duchamp, Bonaventure Tchaleu Ngadjui, Marie Aleth Lacaille-Dubois

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

Three new steroidal saponins, named diospreussinosides A-C (1-3), along with two known ones (4, 5) were isolated from rhizomes of Dioscorea preussii. Their structures were elucidated mainly by 1D and 2D NMR spectroscopic analysis and mass spectrometry as (25S)-17α,25-dihydroxyspirost-5-en-3β-yl-O- α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranoside (1), (25S)-17α,25-dihydroxyspirost-5-en- 3β-yl-O-α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-glucopyranoside (2), and (24S,25R)-17α,24,25-trihydroxyspirost-5-en-3β-yl-O-α- l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-glucopyranoside (3). The spirostane-type skeleton of compound 3 possessing an unusual dihydroxylation pattern on the F-ring is reported for the first time. Cytotoxicity of compounds 2-5 was evaluated against two human colon carcinoma cell lines (HT-29 and HCT 116).

元の言語英語
ページ(範囲)198-203
ページ数6
ジャーナルFitoterapia
97
DOI
出版物ステータス出版済み - 1 1 2014

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Dioscorea
Rhizome
Saponins
Skeleton
Mass Spectrometry
Colon
Carcinoma
Cell Line

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

これを引用

Tabopda, T. K., Mitaine-Offer, A. C., Tanaka, C., Miyamoto, T., Mirjolet, J. F., Duchamp, O., ... Lacaille-Dubois, M. A. (2014). Steroidal saponins from dioscorea preussii. Fitoterapia, 97, 198-203. https://doi.org/10.1016/j.fitote.2014.06.006

Steroidal saponins from dioscorea preussii. / Tabopda, Turibio Kuiate; Mitaine-Offer, Anne Claire; Tanaka, Chiaki; Miyamoto, Tomofumi; Mirjolet, Jean François; Duchamp, Olivier; Ngadjui, Bonaventure Tchaleu; Lacaille-Dubois, Marie Aleth.

:: Fitoterapia, 巻 97, 01.01.2014, p. 198-203.

研究成果: ジャーナルへの寄稿記事

Tabopda, TK, Mitaine-Offer, AC, Tanaka, C, Miyamoto, T, Mirjolet, JF, Duchamp, O, Ngadjui, BT & Lacaille-Dubois, MA 2014, 'Steroidal saponins from dioscorea preussii', Fitoterapia, 巻. 97, pp. 198-203. https://doi.org/10.1016/j.fitote.2014.06.006
Tabopda TK, Mitaine-Offer AC, Tanaka C, Miyamoto T, Mirjolet JF, Duchamp O その他. Steroidal saponins from dioscorea preussii. Fitoterapia. 2014 1 1;97:198-203. https://doi.org/10.1016/j.fitote.2014.06.006
Tabopda, Turibio Kuiate ; Mitaine-Offer, Anne Claire ; Tanaka, Chiaki ; Miyamoto, Tomofumi ; Mirjolet, Jean François ; Duchamp, Olivier ; Ngadjui, Bonaventure Tchaleu ; Lacaille-Dubois, Marie Aleth. / Steroidal saponins from dioscorea preussii. :: Fitoterapia. 2014 ; 巻 97. pp. 198-203.
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abstract = "Three new steroidal saponins, named diospreussinosides A-C (1-3), along with two known ones (4, 5) were isolated from rhizomes of Dioscorea preussii. Their structures were elucidated mainly by 1D and 2D NMR spectroscopic analysis and mass spectrometry as (25S)-17α,25-dihydroxyspirost-5-en-3β-yl-O- α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranoside (1), (25S)-17α,25-dihydroxyspirost-5-en- 3β-yl-O-α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-glucopyranoside (2), and (24S,25R)-17α,24,25-trihydroxyspirost-5-en-3β-yl-O-α- l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-glucopyranoside (3). The spirostane-type skeleton of compound 3 possessing an unusual dihydroxylation pattern on the F-ring is reported for the first time. Cytotoxicity of compounds 2-5 was evaluated against two human colon carcinoma cell lines (HT-29 and HCT 116).",
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AU - Mirjolet, Jean François

AU - Duchamp, Olivier

AU - Ngadjui, Bonaventure Tchaleu

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