Steroidogenic Factor 1 (NR5A1) resides in centrosomes and maintains genomic stability by controlling centrosome homeostasis

P. Y. Lai, C. Y. Wang, W. Y. Chen, Y. H. Kao, H. M. Tsai, T. Tachibana, W. C. Chang, B. C. Chung

研究成果: ジャーナルへの寄稿学術誌査読

21 被引用数 (Scopus)

抄録

SF-1 (Steroidogenic Factor 1, NR5A1) is a tissue-specific transcription factor critical for the growth, development and differentiation of steroidogenic and a few other endocrine tissues. But how SF-1 regulates cell growth is not entirely clear. Here we found that SF-1 was localized to the centrosome in addition to the nucleus, and SF-1 depletion by shRNA caused centrosome over-duplication, aberrant mitosis and genomic instability, leading to a reduction of cell number. Centrosome amplification defect was rescued by both wild-type SF-1 and transcription-defective SF-1-G35E, suggesting a non-genomic activity of SF-1 involved in centrosome homeostasis. In addition, we identified in SF-1 a centrosome localization signal, whose overexpression led to reduced localization of both SF-1 and γ-tubulin to the centrosome. Our results uncover a novel role of SF-1 in the control of centrosome homeostasis and genomic stability.

本文言語英語
ページ(範囲)1836-1844
ページ数9
ジャーナルCell Death and Differentiation
18
12
DOI
出版ステータス出版済み - 12月 2011

!!!All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 細胞生物学

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