Stimulation of food intake after central administration of gonadotropin-inhibitory hormone is similar in genetically selected low and high body weight lines of chickens

Betty R. McConn, Jiaqing Yi, Elizabeth R. Gilbert, Paul B. Siegel, Vishwajit S. Chowdhury, Mitsuhiro Furuse, Mark A. Cline

研究成果: ジャーナルへの寄稿記事

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Gonadotropin-inhibitory hormone (GnIH), first isolated from the brain of the Japanese quail (Coturnix japonica), when centrally administered exerts orexigenic effects in birds. However, the precise mechanisms mediating this effect are poorly understood and limited information is available on this effect in models of body weight dysfunction. Thus, the purpose of the present study was to investigate appetite-associated effects of GnIH in chicks from lines that have been selected for either low or high body weight, and are anorexic or become obese, respectively. Central GnIH injection increased food intake in both lines with a similar magnitude of response. There was no effect on water intake. Hypothalamic GnIH mRNA was greater in the low than high weight lines and was greater in the fasted than fed chicks. GnIH receptor mRNA was similarly expressed in both lines, and was greater in fed than fasted chicks. Thus, although selection for body weight did not alter the effect of GnIH on feeding, fasting increased GnIH mRNA in both lines implying that it is an innate hunger factor.

元の言語英語
ページ(範囲)96-100
ページ数5
ジャーナルGeneral and Comparative Endocrinology
232
DOI
出版物ステータス出版済み - 6 1 2016

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All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • Endocrinology

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