Stimuli-responsive liposome aggregation induced by DNA-surfactants

Tatsuo Maruyama, Mai Hiraki, Hiroshi Yamamura, Harumi Takata, Masahiro Goto

研究成果: Contribution to conferencePaper査読

抄録

Here we describe a novel strategy of liposome aggregation employing DNA-surfactant, in which the aggregation of liposomes can be reversibly controlled by enzyme stimuli and temperature. Single-stranded oligonucleotides (24-mer) were bound to oleic acid to produce DNA-surfactant. The DNA surfactant was mixed with POPC liposomes to prepare DNA-tethered liposomes. Mixing of the DNA-tagged liposomes with ones bearing complementary DNA strands starts the aggregation of liposomes. The liposomes were linked with each other via duplex DNA. We found that the liposome aggregation was influenced by temperature, salt concentration and restriction enzyme.

本文言語英語
ページ3873-3874
ページ数2
出版ステータス出版済み - 12 1 2005
イベント54th SPSJ Symposium on Macromolecules - Yamagata, 日本
継続期間: 9 20 20059 22 2005

その他

その他54th SPSJ Symposium on Macromolecules
Country日本
CityYamagata
Period9/20/059/22/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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