Stroke and cerebrovascular diseases in patients with chronic kidney disease

Kazunori Toyoda, Toshiharu Ninomiya

研究成果: ジャーナルへの寄稿評論記事

120 引用 (Scopus)

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Chronic kidney disease, defined as a reduced glomerular filtration rate or increased urinary albumin excretion, is recognised as a rapidly growing global health burden, and increasing evidence suggests that it contributes to the risk and severity of cerebrovascular diseases. In particular, chronic kidney disease is an established risk factor for stroke and is also strongly associated with subclinical cerebrovascular abnormalities and cognitive impairment, partly because it shares several traditional and non-traditional risk factors, and sometimes uraemia-related and dialysis-related factors, with cerebrovascular diseases. The effect of chronic kidney disease on incident stroke differs among regions and races and is greater in Asian than in non-Asian people. Chronic kidney disease seems to be predictive of severe neurological deficits and poor vital and functional outcomes after both ischaemic and haemorrhagic strokes, which is partly due to the limitations of pharmacotherapies, including limited use and effects of novel oral anticoagulants, other antithrombotic treatments, and reperfusion treatment for hyperacute ischaemic stroke. In view of the strong two-way association between stroke and kidney disease, the pathophysiological interactions between the brain and kidney should be the subject of intensive study.

元の言語英語
ページ(範囲)823-833
ページ数11
ジャーナルThe Lancet Neurology
13
発行部数8
DOI
出版物ステータス出版済み - 8 2014

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All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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