Stromal keratitis induced by a unique clinical isolate of herpes simplex virus type 1

Yuichiro Sakai, Hiroko Minagawa, Tatsuro Ishibashi, Hajime Inomata, Ryoichi Mori

研究成果: Contribution to journalArticle

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抜粋

Glycoprotein C (gC)-negative clinical isolates of herpes simplex virus type I (HSV-1) are very rare. An HSV-1 strain (TN-1), isolated from a patient with herpetic keratitis, exhibited a gC-negative phenotype. While a gC-negative mutant showed reduced pathogenicity and failed to induce herpetic stromal keratitis (HSK) in a previously reported mouse model, TN-1 induced HSK in mice comparable to RTN-1-20-3, a gC-positive recombinant virus derived from TN-1. Virus growth in eyes and brains and the mortality of TN-1-inoculated mice were equal to or higher than those of RTN-l-20-3-inoculated mice.

元の言語英語
ページ(範囲)157-160
ページ数4
ジャーナルOphthalmologica
208
発行部数3
DOI
出版物ステータス出版済み - 1 1 1994

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems

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