TY - JOUR
T1 - Strong chemiluminescence intensities of bis-acridinium esters under neutral and alkaline conditions
AU - Nakazono, Manabu
AU - Hamase, Kenji
N1 - Funding Information:
This research was supported by Kakihara Science and Technology Research Foundation (Grant No. 2-9-1). High-resolution mass spectra were obtained from the results of the use of research equipment shared in a MEXT Project for the promotion of the public utilization of advanced research infrastructure (Program supporting the introduction of the new sharing system, Grant No. JPMXS0422300120). We appreciate technical assistance provided by The Research Support Center, Research Center for Human Disease Modeling, Kyushu University Graduate School of Medical Sciences. We would like to thank Prof. Takashi Ito (Graduate School of Medical Sciences, Kyushu University) and Prof. Satoshi Okada (Graduate School of Medical Sciences, Kyushu University) for the measurement of chemiluminescence emission spectra.
Funding Information:
This research was supported by Kakihara Science and Technology Research Foundation (Grant No. 2-9-1 ). High-resolution mass spectra were obtained from the results of the use of research equipment shared in a MEXT Project for the promotion of the public utilization of advanced research infrastructure (Program supporting the introduction of the new sharing system, Grant No. JPMXS0422300120 ). We appreciate technical assistance provided by The Research Support Center, Research Center for Human Disease Modeling, Kyushu University Graduate School of Medical Sciences. We would like to thank Prof. Takashi Ito (Graduate School of Medical Sciences, Kyushu University) and Prof. Satoshi Okada (Graduate School of Medical Sciences, Kyushu University) for the measurement of chemiluminescence emission spectra.
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/5
Y1 - 2023/5
N2 - Four novel bis-acridinium esters were synthesized using common methods, and their chemiluminescence properties were investigated at pH 7−10. In the chemiluminescence of bis-acridinium esters, the introduction of fluorine at the 2-position of the phenyl ring and methyl groups at the 2,7-positions of the acridine ring changed greatly the chemiluminescence intensities. Pentane-1,5-diyl bis(2-fluoro-4-(2,7,10-trimethylacridinium-9-carbonyloxy)benzoate) bis(trifluoromethanesulfonate) showed strong chemiluminescence and long-lasting chemiluminescence under both neutral and alkaline conditions. Pentane-1,5-diyl bis(2-fluoro-4-(10-methylacridinium-9-carbonyloxy)benzoate) bis(trifluoromethanesulfonate) was applied for highly sensitive chemiluminescence determination of hydrogen peroxide and catalase activity. The linear calibration ranges of hydrogen peroxide and catalase activity were 5–1000 μM (R = 0.999) and 0.05−1 U/mL (R = 0.998), respectively.
AB - Four novel bis-acridinium esters were synthesized using common methods, and their chemiluminescence properties were investigated at pH 7−10. In the chemiluminescence of bis-acridinium esters, the introduction of fluorine at the 2-position of the phenyl ring and methyl groups at the 2,7-positions of the acridine ring changed greatly the chemiluminescence intensities. Pentane-1,5-diyl bis(2-fluoro-4-(2,7,10-trimethylacridinium-9-carbonyloxy)benzoate) bis(trifluoromethanesulfonate) showed strong chemiluminescence and long-lasting chemiluminescence under both neutral and alkaline conditions. Pentane-1,5-diyl bis(2-fluoro-4-(10-methylacridinium-9-carbonyloxy)benzoate) bis(trifluoromethanesulfonate) was applied for highly sensitive chemiluminescence determination of hydrogen peroxide and catalase activity. The linear calibration ranges of hydrogen peroxide and catalase activity were 5–1000 μM (R = 0.999) and 0.05−1 U/mL (R = 0.998), respectively.
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U2 - 10.1016/j.dyepig.2023.111175
DO - 10.1016/j.dyepig.2023.111175
M3 - Article
AN - SCOPUS:85148544596
SN - 0143-7208
VL - 213
JO - Dyes and Pigments
JF - Dyes and Pigments
M1 - 111175
ER -