Structural analysis by NMR of antitumor drug-DNA complexes: 9-aminoanthracycline (SM-5887)

Jun etsu Igarashi, Makoto Sunagawa

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

SM-5887 is an anthracycline antibiotic with a potent antitumor activity and low toxicity. The structure of the 2:1 SM-5887 -d(CGTACG) complex has been studied in solution by 2D NMR spectroscopy. These data revealed that SM-5887 intercalated between the cytosine and guanine residues and the sugar moiety lay in the minor groove. The intercalation geometry of SM-5887 was a hybrid between those of adriamycin and nogalamycin.

本文言語英語
ページ(範囲)2923-2928
ページ数6
ジャーナルBioorganic and Medicinal Chemistry Letters
5
23
DOI
出版ステータス出版済み - 12 7 1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

フィンガープリント 「Structural analysis by NMR of antitumor drug-DNA complexes: 9-aminoanthracycline (SM-5887)」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル