Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity

Daisuke Takahashi, Sanjeev K. Shukla, Om Prakash, Guolong Zhang

研究成果: ジャーナルへの寄稿総説査読

219 被引用数 (Scopus)

抄録

Antimicrobial host defense peptides (HDPs) are a critical component of the innate immunity with microbicidal, endotoxin-neutralizing, and immunostimulatory properties. HDPs kill bacteria primarily through non-specific membrane lysis, therefore with a less likelihood of provoking resistance. Extensive structure-activity relationship studies with a number of HDPs have revealed that net charge, amphipathicity, hydrophobicity, and structural propensity are among the most important physicochemical and structural parameters that dictate their ability to interact with and disrupt membranes. A delicate balance among these factors, rather than a mere alteration of a single factor, is critically important for HDPs to ensure the antimicrobial potency and target cell selectivity. With a better understanding of the structural determinants of HDPs for their membrane-lytic activities, it is expected that novel HDP-based antimicrobials with minimum toxicity to eukaryotic cells can be developed for resistant infections, which have become a global public health crisis.

本文言語英語
ページ(範囲)1236-1241
ページ数6
ジャーナルBiochimie
92
9
DOI
出版ステータス出版済み - 9月 2010
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生化学

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