Structural reevaluations of amphidinol 3, a potent antifungal compound from dinoflagellate

Respati T. Swasono; Mitsunori Kanemoto; Nobuaki Matsumori; Tohru Oishi; Michio Murata

doi:10.3987/COM-10-S(E)86

Structural reevaluations of amphidinol 3, a potent antifungal compound from dinoflagellate

Respati T. Swasono, Mitsunori Kanemoto, Nobuaki Matsumori, Tohru Oishi, Michio Murata

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

11 被引用数 (Scopus)

抄録

Among other homologues, amphidinol 3 (AM3) is the most potent antifungal compound isolated from the dinoflagellate Amphidinium klebsii. AM3 undergoes conformational changes in organic solvents while it takes relatively fixed configuration in a membrane model. By using NMR data of peracetyl AM3, we were able to confirm the configuration of C50-C51 of AM3 which remained uncertain in our previous study.

本文言語	英語
ページ（範囲）	1359-1369
ページ数	11
ジャーナル	Heterocycles
巻	82
号	2
DOI	https://doi.org/10.3987/COM-10-S(E)86
出版ステータス	出版済み - 2月 28 2010
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

分析化学
薬理学
有機化学

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10.3987/COM-10-S(E)86

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AU - Swasono, Respati T.

AU - Kanemoto, Mitsunori

AU - Matsumori, Nobuaki

AU - Oishi, Tohru

AU - Murata, Michio

PY - 2010/2/28

Y1 - 2010/2/28

N2 - Among other homologues, amphidinol 3 (AM3) is the most potent antifungal compound isolated from the dinoflagellate Amphidinium klebsii. AM3 undergoes conformational changes in organic solvents while it takes relatively fixed configuration in a membrane model. By using NMR data of peracetyl AM3, we were able to confirm the configuration of C50-C51 of AM3 which remained uncertain in our previous study.

AB - Among other homologues, amphidinol 3 (AM3) is the most potent antifungal compound isolated from the dinoflagellate Amphidinium klebsii. AM3 undergoes conformational changes in organic solvents while it takes relatively fixed configuration in a membrane model. By using NMR data of peracetyl AM3, we were able to confirm the configuration of C50-C51 of AM3 which remained uncertain in our previous study.

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Structural reevaluations of amphidinol 3, a potent antifungal compound from dinoflagellate

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!!!All Science Journal Classification (ASJC) codes

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