Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum

Jie Liu, Kenji Kurashiki, Kuniyoshi Shimizu, Ryuichiro Kondo

研究成果: ジャーナルへの寄稿記事

48 引用 (Scopus)

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In humans, 5α-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5α-reductase activity. The presence of the C-3 carbonyl group and of the C-26-α,β-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum.

元の言語英語
ページ(範囲)8654-8660
ページ数7
ジャーナルBioorganic and Medicinal Chemistry
14
発行部数24
DOI
出版物ステータス出版済み - 12 15 2006

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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