Structure of the human prealbumin gene

Teruhisa Tsuzuki, S. Mita, S. Maeda, S. Araki, K. Shimada

研究成果: ジャーナルへの寄稿記事

127 引用 (Scopus)

抄録

Using cloned human prealbumin cDNA as a probe, Southern blot hybridization of human genomic DNA revealed that the prealbumin gene consists of an unique, single-copy DNA. The nucleotide sequences of the entire human prealbumin gene, including both 581 base pairs of the 5'- and 95 base pairs of the 3'-flanking sequences, were determined. The gene spans about 7.0 kilobase pairs and consists of four exons and three introns. As in most eukaryotic genes, the consensus TATA and CAAT sequences were found 30 and 101 nucleotides, respectively, upstream from the putative cap site, and a polyadenylation signal sequence AATAAA is found in the 3'-untranslated region. Unexpectedly, two independent open reading frames provided with respective regulatory sequences were found within the gene: one in the first intron and the other in the third intron.

元の言語英語
ページ(範囲)12224-12227
ページ数4
ジャーナルJournal of Biological Chemistry
260
発行部数22
出版物ステータス出版済み - 12 1 1985

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Prealbumin
Genes
Introns
Base Pairing
Nucleotides
3' Flanking Region
Nucleic Acid Hybridization
Polyadenylation
DNA
3' Untranslated Regions
Protein Sorting Signals
Southern Blotting
Open Reading Frames
Exons
Complementary DNA

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Tsuzuki, T., Mita, S., Maeda, S., Araki, S., & Shimada, K. (1985). Structure of the human prealbumin gene. Journal of Biological Chemistry, 260(22), 12224-12227.

Structure of the human prealbumin gene. / Tsuzuki, Teruhisa; Mita, S.; Maeda, S.; Araki, S.; Shimada, K.

:: Journal of Biological Chemistry, 巻 260, 番号 22, 01.12.1985, p. 12224-12227.

研究成果: ジャーナルへの寄稿記事

Tsuzuki, T, Mita, S, Maeda, S, Araki, S & Shimada, K 1985, 'Structure of the human prealbumin gene', Journal of Biological Chemistry, 巻. 260, 番号 22, pp. 12224-12227.
Tsuzuki T, Mita S, Maeda S, Araki S, Shimada K. Structure of the human prealbumin gene. Journal of Biological Chemistry. 1985 12 1;260(22):12224-12227.
Tsuzuki, Teruhisa ; Mita, S. ; Maeda, S. ; Araki, S. ; Shimada, K. / Structure of the human prealbumin gene. :: Journal of Biological Chemistry. 1985 ; 巻 260, 番号 22. pp. 12224-12227.
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