Structure-specific DNA nucleases: Structural basis for 3D-scissors

Tatsuya Nishino, Yoshizumi Ishino, Kosuke Morikawa

研究成果: Contribution to journalReview article査読

22 被引用数 (Scopus)


Structure-specific DNA nucleases play important roles in various DNA transactions such as DNA replication, repair and recombination. These enzymes recognize loops and branched DNA structures. Recent structural studies have provided detailed insights into the functions of these enzymes. Structures of Holliday junction resolvase revealed that nucleases are broadly diverged in the way in which they fold, however, are required to form homodimers with large basic patches of protein surfaces, which are complementary to DNA tertiary structures. Many nucleases maintain structure-specific recognition modes, which involve particular domain arrangements through conformal changes of flexible loops or have a separate DNA binding domain. Nucleases, such as FEN-1 and archaeal XPF, are bound to proliferating cell nuclear antigen through a common motif, and thereby actualize their inherent activities.

ジャーナルCurrent Opinion in Structural Biology
出版ステータス出版済み - 2 2006

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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