Structures and biosynthesis of aflastatins: Novel inhibitors of aflatoxin production by Aspergillus parasiticus

Makoto Ono, Shohei Sakuda, Hiroyuki Ikeda, Kazuo Furihata, Jiro Nakayama, Akinori Suzuki, Akira Isogai

研究成果: ジャーナルへの寄稿学術誌査読

35 被引用数 (Scopus)

抄録

Two novel inhibitors of aflatoxin production by Aspergillus parasiticus were isolated from the mycelial extracts of Streptomyces sp. MRI142 and termed aflastatin A and B. The structures of aflastatin A (1) and B (5) were elucidated by NMR and chemical degradation experiments. These compounds have a novel skeleton of a tetramic acid derivative with a highly oxygenated long alkyl chain. The incorporation experiments using 13C-labeled acetates, propionate, glucose and glycolate suggested that most of the C2 and C3 units involved in the alkyl chain moiety of aflastatin A were biosynthesized from acetic and propionic acids, but five C2 units in the alkyl chain originated from glycolic acid.

本文言語英語
ページ(範囲)1019-1028
ページ数10
ジャーナルJournal of Antibiotics
51
11
DOI
出版ステータス出版済み - 11月 1998
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 創薬

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