Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity

T. Horiuchi, H. Fujiki, M. Suganuma, H. Hakii, M. Nakayasu, Y. Hitotsuyanagi, N. Aimi, S. Sakai, Y. Endo, K. Shudo

研究成果: Contribution to journalArticle査読

18 被引用数 (Scopus)

抄録

Three olivoretins, A, B and C (isolated from Streptoverticillium olivoreticuli), which are O-methylated teleocidin B isomers, were found to be biologically inactive. A fourth olivoretin, D, which has a free hydroxyl group and is identical to one of the four teleocidin B isomers, teleocidin B-4 (teleocidin B of Hirata) was biologically active. These findings indicate that the free primary hydroxyl group of teleocidin B isomers is necessary for activity. The effect on biological activity of the structural difference between des-O-methyl-olivoretin B (teleocidin B-1) and des-O-methylolivoretin C was also studied.

本文言語英語
ページ(範囲)837-840
ページ数4
ジャーナルGann, The Japanese Journal of Cancer Research
75
10
出版ステータス出版済み - 12 1 1984
外部発表はい

All Science Journal Classification (ASJC) codes

  • 癌研究

フィンガープリント

「Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル