Studies on Prodrugs. III. A Convenient and Practical Preparation of Ampicillin Prodrugs

Shoji Ikeda, Fumio Sakamoto, Hirosato Kondo, Masaru Moriyama, Goro Tsukamoto

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

In order to prepare ampicillin prodrugs conveniently for practical use, a new synthetic method for 6β-aminopenicillanic acid (6-APA) esters as key intermediates of various ampicillin prodrugs has been developed. Acylation of 6-APA esters to ampicillin esters was achieved in good yields by using phenylglycyl chloride hydrochloride in dichloromethane in the presence of sodium bicarbonate and amide, or ammonium bicarbonate alone. KBT-1585, bacampicillin, talampicillin and pivampicillin have been obtained in good yields by this procedure.

本文言語英語
ページ(範囲)4316-4322
ページ数7
ジャーナルChemical and Pharmaceutical Bulletin
32
11
DOI
出版ステータス出版済み - 1984
外部発表はい

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 創薬

フィンガープリント

「Studies on Prodrugs. III. A Convenient and Practical Preparation of Ampicillin Prodrugs」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル