Studies on the formation mechanism and the structure of the anisotropic collagen gel prepared by dialysis-induced anisotropic gelation

Kazuya Furusawa, Shoichi Sato, Jyun Ichi Masumoto, Yohei Hanazaki, Yasuyuki Maki, Toshiaki Dobashi, Takao Yamamoto, Akimasa Fukui, Naoki Sasaki

研究成果: Contribution to journalArticle査読

28 被引用数 (Scopus)

抄録

We have found that dialysis of 5 mg/mL collagen solution into the phosphate solution with a pH of 7.1 and an ionic strength of 256 mM at 25 °C results in a collagen gel with a birefringence and tubular pores aligned parallel to the growth direction of the gel. The time course of averaged diameter of tubular pores during the anisotropic gelation was expressed by a power law with an exponent of 1/3, suggesting that the formation of tubular pores is attributed to a spinodal decomposition-like phase separation. Small angle light scattering patterns and high resolution confocal laser scanning microscope images of the anisotropic collagen gel suggested that the collagen fibrils are aligned perpendicular to the growth direction of the gel. The positional dependence of the order parameter of the collagen fibrils showed that the anisotropic collagen gel has an orientation gradient.

本文言語英語
ページ(範囲)29-39
ページ数11
ジャーナルBiomacromolecules
13
1
DOI
出版ステータス出版済み - 1 9 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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