抄録
D -Amino acids, long-term undetected enantiomers of L -amino acids, are now emerging as potential biomarkers, especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its high prevalence and poor prognosis, is currently unsatisfactory due to the difficulty in estimating kidney function and in early detection of diseases. We now show that intra-body dynamics of D -serine reflect kidney function and diseases. The blood level of D -serine correlated well with the actual glomerular filtration ratio, a key kidney function. This correlation was compatible with those of conventional kidney markers, and blood level of D -serine was relatively unaffected by such clinical factors as body size. The balance between excretion and reabsorption of amino acids by the kidney was controlled with chiral selectivity, and the reabsorption of D -serine was sensitive to the presence of CKD. The combination of blood level and urinary dynamics of D -serine effectively distinguished CKD from non-CKD. These lines of evidence provide new insights into the enantioselective amino acid dynamics in the human body that reflect disease pathophysiology. D -Serine may serve as a vital biomarker that suppress CKD onset through the precise assessment of kidney function and the diagnosis of CKD.
| 元の言語 | 英語 |
|---|---|
| 記事番号 | 5104 |
| ジャーナル | Scientific reports |
| 巻 | 9 |
| 発行部数 | 1 |
| DOI | |
| 出版物ステータス | 出版済み - 12 1 2019 |
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All Science Journal Classification (ASJC) codes
- General
これを引用
D -Serine reflects kidney function and diseases . / Hesaka, Atsushi; Sakai, Shinsuke; Hamase, Kenji; Ikeda, Tatsuhiko; Matsui, Rakan; Mita, Masashi; Horio, Masaru; Isaka, Yoshitaka; Kimura, Tomonori.
：: Scientific reports, 巻 9, 番号 1, 5104, 01.12.2019.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - D -Serine reflects kidney function and diseases
AU - Hesaka, Atsushi
AU - Sakai, Shinsuke
AU - Hamase, Kenji
AU - Ikeda, Tatsuhiko
AU - Matsui, Rakan
AU - Mita, Masashi
AU - Horio, Masaru
AU - Isaka, Yoshitaka
AU - Kimura, Tomonori
PY - 2019/12/1
Y1 - 2019/12/1
N2 - D -Amino acids, long-term undetected enantiomers of L -amino acids, are now emerging as potential biomarkers, especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its high prevalence and poor prognosis, is currently unsatisfactory due to the difficulty in estimating kidney function and in early detection of diseases. We now show that intra-body dynamics of D -serine reflect kidney function and diseases. The blood level of D -serine correlated well with the actual glomerular filtration ratio, a key kidney function. This correlation was compatible with those of conventional kidney markers, and blood level of D -serine was relatively unaffected by such clinical factors as body size. The balance between excretion and reabsorption of amino acids by the kidney was controlled with chiral selectivity, and the reabsorption of D -serine was sensitive to the presence of CKD. The combination of blood level and urinary dynamics of D -serine effectively distinguished CKD from non-CKD. These lines of evidence provide new insights into the enantioselective amino acid dynamics in the human body that reflect disease pathophysiology. D -Serine may serve as a vital biomarker that suppress CKD onset through the precise assessment of kidney function and the diagnosis of CKD.
AB - D -Amino acids, long-term undetected enantiomers of L -amino acids, are now emerging as potential biomarkers, especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its high prevalence and poor prognosis, is currently unsatisfactory due to the difficulty in estimating kidney function and in early detection of diseases. We now show that intra-body dynamics of D -serine reflect kidney function and diseases. The blood level of D -serine correlated well with the actual glomerular filtration ratio, a key kidney function. This correlation was compatible with those of conventional kidney markers, and blood level of D -serine was relatively unaffected by such clinical factors as body size. The balance between excretion and reabsorption of amino acids by the kidney was controlled with chiral selectivity, and the reabsorption of D -serine was sensitive to the presence of CKD. The combination of blood level and urinary dynamics of D -serine effectively distinguished CKD from non-CKD. These lines of evidence provide new insights into the enantioselective amino acid dynamics in the human body that reflect disease pathophysiology. D -Serine may serve as a vital biomarker that suppress CKD onset through the precise assessment of kidney function and the diagnosis of CKD.
UR - http://www.scopus.com/inward/record.url?scp=85063426837&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063426837&partnerID=8YFLogxK
U2 - 10.1038/s41598-019-41608-0
DO - 10.1038/s41598-019-41608-0
M3 - Article
C2 - 30911057
AN - SCOPUS:85063426837
VL - 9
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 5104
ER -