Successful allogeneic stem cell transplantation in a case with acute myeloid leukemia and invasive Schizophyllum commune rhinosinusitis

Takuya Harada, Takuro Kuriyama, Ruriko Nishida, Goichi Yoshimoto, Yasuo Mori, Hiroshi Imanaga, Toshiyuki Ueno, Jun Odawara, Masayasu Hayashi, Koji Kato, Katsuto Takenaka, Koichi Akashi, Toshihiro Miyamoto

研究成果: Contribution to journalArticle

抜粋

Schizophyllum commune, a basidiomycete fungus, is a quite rare cause of invasive sinusitis for which no standard treatment has yet been established. We report herein a 59-year-old woman who developed S. commune rhinosinusitis after remission induction chemotherapy for her acute myeloid leukemia. No causative microorganisms were identified in the sinus lavage fluid culture, whereas nucleotide sequencing of the internal transcribed spacer region using endoscopic sinus biopsy specimen could confirm the pathogen as S. commune. Liposomal amphotericin B and voriconazole (VRCZ) treatment ameliorated both her clinical symptoms and laboratory findings. The patient was successfully treated with allogeneic stem cell transplantation, under continuous VRCZ administration, without aggravation of S. commune sinusitis. Molecular diagnosis and prompt intervention with suitable antifungal drugs may be crucial to manage this rare infectious complication.

元の言語英語
ページ(範囲)506-509
ページ数4
ジャーナルJournal of Infection and Chemotherapy
26
発行部数5
DOI
出版物ステータス出版済み - 5 2020

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

フィンガープリント Successful allogeneic stem cell transplantation in a case with acute myeloid leukemia and invasive Schizophyllum commune rhinosinusitis' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用