Successful allogeneic stem cell transplantation in two patients with acute myelogenous leukaemia and invasive aspergillosis by antifungal combination therapy

Takatoshi Aoki, Toshihiro Miyamoto, Yasuo Mori, Goichi Yoshimoto, takuji yamauchi, Kenjiro Kamezaki, Katsuto Takenaka, Hiromi Iwasaki, Naoki Harada, Koji Nagafuji, Nobuyuki Shimono, Takanori Teshima, Koichi Akashi

研究成果: ジャーナルへの寄稿レター

3 引用 (Scopus)

抄録

Invasive aspergillosis (IA) is an important cause of infectious morbidity and mortality in patients who undergo haematopoietic stem cell transplantation (HSCT). History of IA before allogeneic HSCT is still challenging because of the high risk of recurrence after HSCT. Recent advances in early-stage diagnosis and new, more effective classes of antifungal agents have improved the management of IA in the HSCT recipients. We report two cases with acute myelogenous leukaemia after primary failure of induction chemotherapy with the patients developing pulmonary IA. They responded well to a combination of voriconazole (VCZ) and micafungin, resulting in a remarkable reduction of pulmonary IA lesions at short intervals. Thereafter, antifungal therapy was switched to liposomal amphotericin B (L-AmB), followed by conditioning regimen for allogeneic HSCT, because of the possibility of VCZ altering the metabolism of chemotherapeutic agents and calcineurin inhibitors. Successful engraftment was achieved without severe adverse side-effects or aggravation of IA after HSCT. Combining VCZ with micafungin followed by L-AmB throughout HSCT could be advantageous in stabilising IA in HSCT patients.

元の言語英語
ジャーナルMycoses
54
発行部数4
DOI
出版物ステータス出版済み - 7 2011

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Aspergillosis
Hematopoietic Stem Cell Transplantation
Stem Cell Transplantation
Acute Myeloid Leukemia
Invasive Pulmonary Aspergillosis
Therapeutics
Induction Chemotherapy
Antifungal Agents
Early Diagnosis
Morbidity
Recurrence
Mortality

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

これを引用

Successful allogeneic stem cell transplantation in two patients with acute myelogenous leukaemia and invasive aspergillosis by antifungal combination therapy. / Aoki, Takatoshi; Miyamoto, Toshihiro; Mori, Yasuo; Yoshimoto, Goichi; yamauchi, takuji; Kamezaki, Kenjiro; Takenaka, Katsuto; Iwasaki, Hiromi; Harada, Naoki; Nagafuji, Koji; Shimono, Nobuyuki; Teshima, Takanori; Akashi, Koichi.

:: Mycoses, 巻 54, 番号 4, 07.2011.

研究成果: ジャーナルへの寄稿レター

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AU - Yoshimoto, Goichi

AU - yamauchi, takuji

AU - Kamezaki, Kenjiro

AU - Takenaka, Katsuto

AU - Iwasaki, Hiromi

AU - Harada, Naoki

AU - Nagafuji, Koji

AU - Shimono, Nobuyuki

AU - Teshima, Takanori

AU - Akashi, Koichi

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