Successful chemotherapeutic treatment for metastatic littoral cell angioma

A case report

Kotoe Takayoshi, Goro Doi, Nobuhiro Tsuruta, Tomoyasu Yoshihiro, Kenta Nio, Kenji Tsuchihashi, hiroshi ariyama, Jun Odawara, Shinji Shimoda, Kenichi Kouhashi, Yoshinao Oda, shinji itoh, Norifumi Harimoto, Yoshihiko Maehara, Hitoshi Kusaba, Koichi Akashi, Eishi Baba

研究成果: ジャーナルへの寄稿記事

抄録

Rationale:Metastatic littoral cell angioma (LCA) is extremely rare. No standard therapeutic strategy has been established, and the impact of chemotherapy has not yet been evaluated.Patient concerns:A 61-year-old woman was admitted because of bicytopenia. She had a splenectomy for LCA of the spleen 10 years earlier. Bone marrow aspiration was normal, and a computed tomography (CT) scan showed hepatomegaly with multiple liver tumors. Diagnoses:Liver biopsy samples showed macrophage-like cell infiltration in the hepatic sinusoids. Metastatic LCA was diagnosed based on immunohistochemistry, imaging tests, and the clinical course.Interventions:Immunosuppressive agents, such as prednisolone and cyclosporine, were ineffective. Next, cytotoxic agents, such as etoposide, paclitaxel, and vincristine, were administered.Outcomes:Cytotoxic agents showed a prominent effect against LCA. CT showed improvement of the hepatomegaly, and fluoro-deoxyglucose (FDG) uptake decreased markedly at a follow-up FDG- positron emission tomography (PET) scan.Lessons:Chemotherapeutic treatment based on hemophagocytic syndrome or angiosarcoma might have anti-tumor activity against metastatic LCA. Analysis of the molecular characteristics of this tumor is needed to develop better treatment options.

元の言語英語
記事番号e0378
ジャーナルMedicine (United States)
97
発行部数15
DOI
出版物ステータス出版済み - 4 1 2018

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Hepatomegaly
Cytotoxins
Deoxyglucose
Liver
Tomography
Hemophagocytic Lymphohistiocytosis
Therapeutics
Neoplasms
Hemangiosarcoma
Vincristine
Etoposide
Splenectomy
Immunosuppressive Agents
Prednisolone
Paclitaxel
Positron-Emission Tomography
Cyclosporine
Bone Marrow
Immunohistochemistry
Macrophages

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Successful chemotherapeutic treatment for metastatic littoral cell angioma : A case report. / Takayoshi, Kotoe; Doi, Goro; Tsuruta, Nobuhiro; Yoshihiro, Tomoyasu; Nio, Kenta; Tsuchihashi, Kenji; ariyama, hiroshi; Odawara, Jun; Shimoda, Shinji; Kouhashi, Kenichi; Oda, Yoshinao; itoh, shinji; Harimoto, Norifumi; Maehara, Yoshihiko; Kusaba, Hitoshi; Akashi, Koichi; Baba, Eishi.

:: Medicine (United States), 巻 97, 番号 15, e0378, 01.04.2018.

研究成果: ジャーナルへの寄稿記事

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abstract = "Rationale:Metastatic littoral cell angioma (LCA) is extremely rare. No standard therapeutic strategy has been established, and the impact of chemotherapy has not yet been evaluated.Patient concerns:A 61-year-old woman was admitted because of bicytopenia. She had a splenectomy for LCA of the spleen 10 years earlier. Bone marrow aspiration was normal, and a computed tomography (CT) scan showed hepatomegaly with multiple liver tumors. Diagnoses:Liver biopsy samples showed macrophage-like cell infiltration in the hepatic sinusoids. Metastatic LCA was diagnosed based on immunohistochemistry, imaging tests, and the clinical course.Interventions:Immunosuppressive agents, such as prednisolone and cyclosporine, were ineffective. Next, cytotoxic agents, such as etoposide, paclitaxel, and vincristine, were administered.Outcomes:Cytotoxic agents showed a prominent effect against LCA. CT showed improvement of the hepatomegaly, and fluoro-deoxyglucose (FDG) uptake decreased markedly at a follow-up FDG- positron emission tomography (PET) scan.Lessons:Chemotherapeutic treatment based on hemophagocytic syndrome or angiosarcoma might have anti-tumor activity against metastatic LCA. Analysis of the molecular characteristics of this tumor is needed to develop better treatment options.",
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T2 - A case report

AU - Takayoshi, Kotoe

AU - Doi, Goro

AU - Tsuruta, Nobuhiro

AU - Yoshihiro, Tomoyasu

AU - Nio, Kenta

AU - Tsuchihashi, Kenji

AU - ariyama, hiroshi

AU - Odawara, Jun

AU - Shimoda, Shinji

AU - Kouhashi, Kenichi

AU - Oda, Yoshinao

AU - itoh, shinji

AU - Harimoto, Norifumi

AU - Maehara, Yoshihiko

AU - Kusaba, Hitoshi

AU - Akashi, Koichi

AU - Baba, Eishi

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