Successful combination chemotherapy for metastatic inflammatory myofibroblastic tumor

A case report

Kyoko Inadomi, Hozumi Kumagai, Kotoe Takayoshi, hiroshi ariyama, Hitoshi Kusaba, Akihiro Nishie, Hidetaka Yamamoto, Ken Takase, Mamoru Tanaka, Kosuke Sagara, Yuta Okumura, Kenta Nio, Michitaka Nakano, Shuji Arita, Yoshinao Oda, Koichi Akashi, Eishi Baba

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

A 64-year-old male presented with increased abdominal fullness and fever. Radiological examination revealed moderate ascites, a tumor with a diameter of 12.5 cm in the mesenteric region, as well as multiple tumors in the thoracic and abdominal para-aortic regions and in the left supraclavicular regions. Pathohistological findings of the biopsy specimen revealed atypical spindle cells accompanied by infiltration of lymphocytes. The plasmacytes were positive for CD68, murine double minute 2 and S-100, while they were negative for α-smooth muscle actin, cyclin-dependent kinase 4 and anaplastic lymphoma kinase. Clinically, the patient presented systemic symptoms and laboratory results indicated an elevation in the inflammatory response, while the CT and MRI findings were consistent with an inflammatory myofibroblastic tumor (IMT). Based on the clinical and histological findings, the patient was diagnosed with IMT. In total, 4 cycles of combination chemotherapy with doxorubicin and ifosfamide were administered. Tumor size reduction by 50% was achieved subsequent to the 4th chemotherapy cycle. In conclusion, successful control of this rare metastatic IMT was achieved by systemic chemotherapy.

元の言語英語
ページ(範囲)2981-2985
ページ数5
ジャーナルOncology Letters
10
発行部数5
DOI
出版物ステータス出版済み - 11 1 2015

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Combination Drug Therapy
Neoplasms
Cyclin-Dependent Kinase 4
Drug Therapy
Ifosfamide
Plasma Cells
Ascites
Doxorubicin
Smooth Muscle
Actins
Fever
Thorax
Lymphocytes
Biopsy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Successful combination chemotherapy for metastatic inflammatory myofibroblastic tumor : A case report. / Inadomi, Kyoko; Kumagai, Hozumi; Takayoshi, Kotoe; ariyama, hiroshi; Kusaba, Hitoshi; Nishie, Akihiro; Yamamoto, Hidetaka; Takase, Ken; Tanaka, Mamoru; Sagara, Kosuke; Okumura, Yuta; Nio, Kenta; Nakano, Michitaka; Arita, Shuji; Oda, Yoshinao; Akashi, Koichi; Baba, Eishi.

:: Oncology Letters, 巻 10, 番号 5, 01.11.2015, p. 2981-2985.

研究成果: ジャーナルへの寄稿記事

Inadomi, Kyoko ; Kumagai, Hozumi ; Takayoshi, Kotoe ; ariyama, hiroshi ; Kusaba, Hitoshi ; Nishie, Akihiro ; Yamamoto, Hidetaka ; Takase, Ken ; Tanaka, Mamoru ; Sagara, Kosuke ; Okumura, Yuta ; Nio, Kenta ; Nakano, Michitaka ; Arita, Shuji ; Oda, Yoshinao ; Akashi, Koichi ; Baba, Eishi. / Successful combination chemotherapy for metastatic inflammatory myofibroblastic tumor : A case report. :: Oncology Letters. 2015 ; 巻 10, 番号 5. pp. 2981-2985.
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abstract = "A 64-year-old male presented with increased abdominal fullness and fever. Radiological examination revealed moderate ascites, a tumor with a diameter of 12.5 cm in the mesenteric region, as well as multiple tumors in the thoracic and abdominal para-aortic regions and in the left supraclavicular regions. Pathohistological findings of the biopsy specimen revealed atypical spindle cells accompanied by infiltration of lymphocytes. The plasmacytes were positive for CD68, murine double minute 2 and S-100, while they were negative for α-smooth muscle actin, cyclin-dependent kinase 4 and anaplastic lymphoma kinase. Clinically, the patient presented systemic symptoms and laboratory results indicated an elevation in the inflammatory response, while the CT and MRI findings were consistent with an inflammatory myofibroblastic tumor (IMT). Based on the clinical and histological findings, the patient was diagnosed with IMT. In total, 4 cycles of combination chemotherapy with doxorubicin and ifosfamide were administered. Tumor size reduction by 50{\%} was achieved subsequent to the 4th chemotherapy cycle. In conclusion, successful control of this rare metastatic IMT was achieved by systemic chemotherapy.",
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AU - Kumagai, Hozumi

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AU - Kusaba, Hitoshi

AU - Nishie, Akihiro

AU - Yamamoto, Hidetaka

AU - Takase, Ken

AU - Tanaka, Mamoru

AU - Sagara, Kosuke

AU - Okumura, Yuta

AU - Nio, Kenta

AU - Nakano, Michitaka

AU - Arita, Shuji

AU - Oda, Yoshinao

AU - Akashi, Koichi

AU - Baba, Eishi

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Y1 - 2015/11/1

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