Successful cyclosporine treatment for thrombocytopenia after salvage therapy with arsenic trioxide therapy followed by autologous hematopoietic stem cell transplantation in acute promyelocytic leukemia

Yasuhiro Nakashima, Yasunobu Abe, Yoshimichi Tachikawa, Rie Ohtsuka, Eriko Sada, Koichiro Muta, Ryoichi Takayanagi

研究成果: Contribution to journalArticle査読

抄録

A 55-year-old man with acute promyelocytic leukemia in the first relapse was treated with arsenic trioxide as salvage therapy. After obtaining molecular remission, he underwent autologous peripheral blood stem cell transplantation (PBSCT) with busulfan and melphalan conditioning. The transplant dose of CD 34-positive cells was sufficient, and engraftment was prompt. Platelet count increased to 320 x 10(9)/1 on day 21; however, it rapidly decreased to 27 x 10(9)/l on day 37. Despite treatment with corticosteroid, the platelet count decreased to 6 x 10(9)/l on day 55. About one month after cyclosporine administration, thrombocytopenia gradually improved. This clinical course suggests immune-mediated thrombocytopenia following autologous PBSCT.

本文言語英語
ページ(範囲)1567-1569
ページ数3
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
48
12
出版ステータス出版済み - 12 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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