Successful labeling of 99mTc-MDP using 99mTc separated from 99Mo produced by 100Mo(n,2n)99Mo

Yasuki Nagai, Yuichi Hatsukawa, Tadahiro Kin, Kazuyuki Hashimoto, Shoji Motoishi, Chikara Konno, Kentaro Ochiai, Kosuke Takakura, Yuichi Sato, Yukimasa Kawauchi, Norihito Sato, Akio Ohta, Hisamichi Yamabayashi, Masakazu Tanase, Saburo Fujisaki, Tomoyuki Teranaka, Nobuhiro Takeuchi, Takashi Igarashi

研究成果: Contribution to journalArticle

13 引用 (Scopus)


We have for the first time succeeded in separating 99mTc from a MoO3 sample irradiated with accelerator neutrons free from any radioactive impurities and in formulating 99mTc-methylene diphosphonate (99mTc-MDP). 99Mo, the mother nuclide of 99mTc, was produced by the 100Mo(n; 2n)99Mo reaction using about 14MeV neutrons provided by the 3H(d; n) 4He reaction at the Fusion Neutronics Source of Japan Atomic Energy Agency. The 99mTc was separated from 99Mo by sublimation and its radionuclide purity was confirmed to be higher than 99.99% by γ-spectroscopy. The labeling efficiency of 99mTc-MDP was shown to be higher than 99% by thin-layer chromatography. These values exceed the United States Pharmacopeia requirements for a fission product, 99Mo. Consequently, a 99mTc radiopharmaceutical preparation formed by using the mentioned 99Mo can be a promising substitute for the fission product 99Mo, which is currently produced using a highly enriched uranium target in aging research reactors. A longstanding problem to ensure a reliable and constant supply of 99Mo in Japan can be partially mitigated.

ジャーナルjournal of the physical society of japan
出版物ステータス出版済み - 8 1 2011

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

フィンガープリント Successful labeling of <sup>99m</sup>Tc-MDP using <sup>99m</sup>Tc separated from <sup>99</sup>Mo produced by <sup>100</sup>Mo(n,2n)<sup>99</sup>Mo' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Nagai, Y., Hatsukawa, Y., Kin, T., Hashimoto, K., Motoishi, S., Konno, C., Ochiai, K., Takakura, K., Sato, Y., Kawauchi, Y., Sato, N., Ohta, A., Yamabayashi, H., Tanase, M., Fujisaki, S., Teranaka, T., Takeuchi, N., & Igarashi, T. (2011). Successful labeling of 99mTc-MDP using 99mTc separated from 99Mo produced by 100Mo(n,2n)99Mo. journal of the physical society of japan, 80(8), [083201].