Successful second autologous blood stem cell transplantation after G-CSF-combined conditioning for the treatment of high-risk acute myelogenous leukemia

Y. Takamatsu, T. Teshima, K. Akashi, S. Inaba, M. Harada, Y. Niho

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

We describe a patient with acute myelogenous leukemia (AML) who received his second autologous blood stem cell transplantation (ABSCT) following a G-CSF-combined pre-transplant conditioning regimen. The patient underwent ABSCT during first remission but suffered a relapse 8 months later. After achieving second remission, he was prepared for his second ABSCT; recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered in combination with Ara C, in addition to the same conditioning regimen as that used before the first ABSCT. There was no increase in regimen-related toxicity after this second G-CSF-combined conditioning regimen when compared with that observed after the first ABSCT. To date, the patient's second remission following the second ABSCT has lasted 26 months, which has exceeded that following the first ABSCT. The G-CSF-combined pretransplant conditioning regimen for ABSCT may be effective in the treatment of high-risk AML by increasing the chemosensitivity of the residual leukemic cells.

本文言語英語
ページ(範囲)325-327
ページ数3
ジャーナルBone Marrow Transplantation
13
3
出版ステータス出版済み - 1 1 1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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