Successful therapy with argatroban for superior mesenteric vein thrombosis in a patient with congenital antithrombin deficiency

Tsuyoshi Muta, Takashi Okamura, Masahiko Kawamoto, Hitoshi Ichimiya, Motoko Yamanaka, Yui Wada, Michiyo Urata, Yuzo Kayamori, Naotaka Hamasaki, Koji Kato, Testuya Eto, Hisashi Gondo, Tsunefumi Shibuya

研究成果: ジャーナルへの寄稿学術誌査読

9 被引用数 (Scopus)

抄録

A 38-year-old woman was admitted with superior mesenteric vein (SMV) thrombosis, which was refractory to anticoagulation therapy. The plasma antithrombin activity was decreased and hardly compensated by concentrated antithrombin preparation due to high consumption rate. However, successful anticoagulation was achieved by administration of direct thrombin inhibitor, argatroban. Family studies of antithrombin activity revealed that she had type I congenital antithrombin deficiency. A novel heterozygous mutation in the gene for antithrombin (single nucleotide T insertion at 7916 and 7917, Glu 272 to stop in exon 4) was identified. Argatroban administration would be effective in the treatment of congenital antithrombin deficiency with SMV thrombosis.

本文言語英語
ページ(範囲)167-170
ページ数4
ジャーナルEuropean Journal of Haematology
75
2
DOI
出版ステータス出版済み - 8月 2005

!!!All Science Journal Classification (ASJC) codes

  • 血液学

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