Suicide and microglia

Recent findings and future perspectives based on human studies

Hisaomi Suzuki, Masahiro Ohgidani, Nobuki Kuwano, Fabrice Chrétien, Geoffroy Lorin de la Grandmaison, Mitsumoto Onaya, Itaru Tominaga, Daiki Setoyama, Dongchon Kang, Masaru Mimura, Shigenobu Kanba, Takahiro Kato

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Suicide is one of the most disastrous outcomes for psychiatric disorders. Recent advances in biological psychiatry have suggested a positive relationship between some specific brain abnormalities and specific symptoms in psychiatric disorders whose organic bases were previously completely unknown. Microglia, immune cells in the brain, are regarded to play crucial roles in brain inflammation by releasing inflammatory mediators and are suggested to contribute to various psychiatric disorders such as depression and schizophrenia. Recently, activated microglia have been suggested to be one of the possible contributing cells to suicide and suicidal behaviors via various mechanisms especially including the tryptophan-kynurenine pathway. Animal model research focusing on psychiatric disorders has a long history, however, there are only limited animal models that can properly express psychiatric symptoms. In particular, to our knowledge, animal models of human suicidal behaviors have not been established. Suicide is believed to be limited to humans, therefore human subjects should be the targets of research despite various ethical and technical limitations. From this perspective, we introduce human biological studies focusing on suicide and microglia. We first present neuropathological studies using the human postmortem brain of suicide victims. Second, we show recent findings based on positron emission tomography (PET) imaging and peripheral blood biomarker analysis on living subjects with suicidal ideation and/or suicide-related behaviors especially focusing on the tryptophan-kynurenine pathway. Finally, we propose future perspectives and tasks to clarify the role of microglia in suicide using multi-dimensional analytical methods focusing on human subjects with suicidal ideation, suicide-related behaviors and suicide victims.

元の言語英語
記事番号31
ページ(範囲)1-10
ページ数10
ジャーナルFrontiers in Cellular Neuroscience
13
DOI
出版物ステータス出版済み - 1 29 2019

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Microglia
Suicide
Psychiatry
Kynurenine
Suicidal Ideation
Animal Models
Tryptophan
Brain
Biological Psychiatry
Encephalitis
Positron-Emission Tomography
Schizophrenia
Biomarkers
History
Depression
Research

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

これを引用

Suzuki, H., Ohgidani, M., Kuwano, N., Chrétien, F., Lorin de la Grandmaison, G., Onaya, M., ... Kato, T. (2019). Suicide and microglia: Recent findings and future perspectives based on human studies. Frontiers in Cellular Neuroscience, 13, 1-10. [31]. https://doi.org/10.3389/fncel.2019.00031

Suicide and microglia : Recent findings and future perspectives based on human studies. / Suzuki, Hisaomi; Ohgidani, Masahiro; Kuwano, Nobuki; Chrétien, Fabrice; Lorin de la Grandmaison, Geoffroy; Onaya, Mitsumoto; Tominaga, Itaru; Setoyama, Daiki; Kang, Dongchon; Mimura, Masaru; Kanba, Shigenobu; Kato, Takahiro.

:: Frontiers in Cellular Neuroscience, 巻 13, 31, 29.01.2019, p. 1-10.

研究成果: ジャーナルへの寄稿記事

Suzuki, H, Ohgidani, M, Kuwano, N, Chrétien, F, Lorin de la Grandmaison, G, Onaya, M, Tominaga, I, Setoyama, D, Kang, D, Mimura, M, Kanba, S & Kato, T 2019, 'Suicide and microglia: Recent findings and future perspectives based on human studies', Frontiers in Cellular Neuroscience, 巻. 13, 31, pp. 1-10. https://doi.org/10.3389/fncel.2019.00031
Suzuki H, Ohgidani M, Kuwano N, Chrétien F, Lorin de la Grandmaison G, Onaya M その他. Suicide and microglia: Recent findings and future perspectives based on human studies. Frontiers in Cellular Neuroscience. 2019 1 29;13:1-10. 31. https://doi.org/10.3389/fncel.2019.00031
Suzuki, Hisaomi ; Ohgidani, Masahiro ; Kuwano, Nobuki ; Chrétien, Fabrice ; Lorin de la Grandmaison, Geoffroy ; Onaya, Mitsumoto ; Tominaga, Itaru ; Setoyama, Daiki ; Kang, Dongchon ; Mimura, Masaru ; Kanba, Shigenobu ; Kato, Takahiro. / Suicide and microglia : Recent findings and future perspectives based on human studies. :: Frontiers in Cellular Neuroscience. 2019 ; 巻 13. pp. 1-10.
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