Sulfated Hyaluronan coating of polyurethanebased implant materials

Ralf Kemkemer, Kiriaki Athanasopulu, Dimitra Caltzidou, Asuka Sekishita, Larysa Kutuzova, Günter Lorenz, Masaru Tanaka

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubberlike properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments.

本文言語英語
論文番号20203115
ジャーナルCurrent Directions in Biomedical Engineering
6
3
DOI
出版ステータス出版済み - 9月 1 2020

!!!All Science Journal Classification (ASJC) codes

  • 生体医工学

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