Sulfated Hyaluronan coating of polyurethanebased implant materials

Ralf Kemkemer, Kiriaki Athanasopulu, Dimitra Caltzidou, Asuka Sekishita, Larysa Kutuzova, Günter Lorenz, Masaru Tanaka

研究成果: Contribution to journalArticle査読

抄録

Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubberlike properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments.

本文言語英語
論文番号20203115
ジャーナルCurrent Directions in Biomedical Engineering
6
3
DOI
出版ステータス出版済み - 9 1 2020

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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