Sulfation and related genes in caenorhabditis elegans

Mizuguchi Souhei, Dejima Katsufumi, Kazuya Nomura

研究成果: ジャーナルへの寄稿評論記事

6 引用 (Scopus)

抄録

Sulfation has become apparent as a critical biomolecule modification, where it plays a major role in homeostasis, development and morphogenesis in organisms ranging from bacteria to humans. Caenorhabditis elegans comprises most of the orthologs of mammalian sulfation-related genes, and it provides a powerful tool to study the various roles of sulfation at a single-cell level. Such a detailed analysis of sulfation is not available in other model organisms, such as Drosophila and mice. In this minireview, we list all the possible, bioinformatically selected, sulfation related genes in this nematode, and review the results of gene knockout experiments (RNAi and deletion mutagenesis) carried out in our laboratory, and by others. Further study using this unique and superior model organism will provide a unique opportunity to review the critical roles of sulfation in multicellular organisms.

元の言語英語
ページ(範囲)179-191
ページ数13
ジャーナルTrends in Glycoscience and Glycotechnology
21
発行部数119
DOI
出版物ステータス出版済み - 5 1 2009

Fingerprint

Caenorhabditis elegans
Genes
Gene Knockout Techniques
RNA Interference
Morphogenesis
Mutagenesis
Drosophila
Homeostasis
Biomolecules
Bacteria
Experiments

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

これを引用

Sulfation and related genes in caenorhabditis elegans. / Souhei, Mizuguchi; Katsufumi, Dejima; Nomura, Kazuya.

:: Trends in Glycoscience and Glycotechnology, 巻 21, 番号 119, 01.05.2009, p. 179-191.

研究成果: ジャーナルへの寄稿評論記事

Souhei, Mizuguchi ; Katsufumi, Dejima ; Nomura, Kazuya. / Sulfation and related genes in caenorhabditis elegans. :: Trends in Glycoscience and Glycotechnology. 2009 ; 巻 21, 番号 119. pp. 179-191.
@article{ea8658eda1394a52a608fa4bf3f1c6c2,
title = "Sulfation and related genes in caenorhabditis elegans",
abstract = "Sulfation has become apparent as a critical biomolecule modification, where it plays a major role in homeostasis, development and morphogenesis in organisms ranging from bacteria to humans. Caenorhabditis elegans comprises most of the orthologs of mammalian sulfation-related genes, and it provides a powerful tool to study the various roles of sulfation at a single-cell level. Such a detailed analysis of sulfation is not available in other model organisms, such as Drosophila and mice. In this minireview, we list all the possible, bioinformatically selected, sulfation related genes in this nematode, and review the results of gene knockout experiments (RNAi and deletion mutagenesis) carried out in our laboratory, and by others. Further study using this unique and superior model organism will provide a unique opportunity to review the critical roles of sulfation in multicellular organisms.",
author = "Mizuguchi Souhei and Dejima Katsufumi and Kazuya Nomura",
year = "2009",
month = "5",
day = "1",
doi = "10.4052/tigg.21.179",
language = "English",
volume = "21",
pages = "179--191",
journal = "Trends in Glycoscience and Glycotechnology",
issn = "0915-7352",
publisher = "Gakushin Publishing Company",
number = "119",

}

TY - JOUR

T1 - Sulfation and related genes in caenorhabditis elegans

AU - Souhei, Mizuguchi

AU - Katsufumi, Dejima

AU - Nomura, Kazuya

PY - 2009/5/1

Y1 - 2009/5/1

N2 - Sulfation has become apparent as a critical biomolecule modification, where it plays a major role in homeostasis, development and morphogenesis in organisms ranging from bacteria to humans. Caenorhabditis elegans comprises most of the orthologs of mammalian sulfation-related genes, and it provides a powerful tool to study the various roles of sulfation at a single-cell level. Such a detailed analysis of sulfation is not available in other model organisms, such as Drosophila and mice. In this minireview, we list all the possible, bioinformatically selected, sulfation related genes in this nematode, and review the results of gene knockout experiments (RNAi and deletion mutagenesis) carried out in our laboratory, and by others. Further study using this unique and superior model organism will provide a unique opportunity to review the critical roles of sulfation in multicellular organisms.

AB - Sulfation has become apparent as a critical biomolecule modification, where it plays a major role in homeostasis, development and morphogenesis in organisms ranging from bacteria to humans. Caenorhabditis elegans comprises most of the orthologs of mammalian sulfation-related genes, and it provides a powerful tool to study the various roles of sulfation at a single-cell level. Such a detailed analysis of sulfation is not available in other model organisms, such as Drosophila and mice. In this minireview, we list all the possible, bioinformatically selected, sulfation related genes in this nematode, and review the results of gene knockout experiments (RNAi and deletion mutagenesis) carried out in our laboratory, and by others. Further study using this unique and superior model organism will provide a unique opportunity to review the critical roles of sulfation in multicellular organisms.

UR - http://www.scopus.com/inward/record.url?scp=70350279305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350279305&partnerID=8YFLogxK

U2 - 10.4052/tigg.21.179

DO - 10.4052/tigg.21.179

M3 - Review article

VL - 21

SP - 179

EP - 191

JO - Trends in Glycoscience and Glycotechnology

JF - Trends in Glycoscience and Glycotechnology

SN - 0915-7352

IS - 119

ER -