Sulfobacins A and B, Novel von Willebrand Factor Receptor Antagonists: I. Production, Isolation, Characterization and Biological Activities

Tsutomu Kamiyama, Takayuki Umino, Tomoko Satoh, Sayoko Sawairi, Michiko Shirane, Shoichi Ohshima, Kazuteru Yokose

研究成果: ジャーナルへの寄稿学術誌査読

39 被引用数 (Scopus)

抄録

Sulfobacins A and B, novel von Willebrand factor (vWF) receptor antagonists, have been isolated from the culture broth of Chryseobacterium sp. (Flavobacterium sp.) NR 2993 by ethyl acetate extraction, and by Sephadex LH-20 and silica gel column chromatographies. The physico-chemical properties of the sulfobacins indicate that their structures are completely different from that of aurintricarboxylic acid, the one known vWF receptor antagonist. Sulfobacins A and B inhibit the binding of vWF to its receptor with IC50s of 0.47 and 2.2 μM, respectively. Sulfobacin A also inhibits ristocetin-induced agglutination in human platelets fixed with paraformaldehyde with an IC50 of 0.58 μM.

本文言語英語
ページ(範囲)924-928
ページ数5
ジャーナルThe Journal of Antibiotics
48
9
DOI
出版ステータス出版済み - 1995

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 創薬

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