11C-methionine uptake in cerebrovascular disease: A comparison with 18F-FDG PET and 99mTc-HMPAO SPECT

Makoto Nakagawa, Yasuo Kuwabara, Masayuki Sasaki, Hirofumi Koga, Tao Chen, Kouichirou Kaneko, Kazutaka Hayashi, Takato Morioka, Kouji Masuda

研究成果: Contribution to journalArticle査読

25 被引用数 (Scopus)

抄録

Objectives: Carbon-11-L-methyl-methionine (11C-methionine) has been reported to be useful for evaluating brain tumors, but several other brain disorders have also shown signs of high methionine uptake. We retrospectively evaluated the significance of 11C-methionine uptake in cerebrovascular diseases, and also compared our results with those for 18F-FDG PET and 99mTc-HMPAO SPECT. Methods: Seven patients, including 3 patients with a cerebral hematoma and 4 patients with a cerebral infarction, were examined. All 7 patients underwent both 11C-methionine PET and 99mTc-HMPAO SPECT, and 6 of them underwent 18F-FDG PET. Results: A high 11C-methionine uptake was observed in all 3 patients with cerebral hematoma. Increased 99mTc-HMPAO uptake was observed in 2 out of 3 patients, and all 3 patients had decreased 18F-FDG uptake. Of 4 patients with a cerebral infarction, high 11C-methionine uptake was observed in 3. Increased 99mTc-HMPAO uptake was also observed in one patient, whereas 3 patients had decreased 18F-FDG uptake. Conclusions: We should keep in mind that high 11C-methionine uptake is frequently observed in cerebrovascular diseases. CVD should therefore be included in the differential diagnosis when encounting patients with a high 11C-methionine uptake.

本文言語英語
ページ(範囲)207-211
ページ数5
ジャーナルAnnals of Nuclear Medicine
16
3
DOI
出版ステータス出版済み - 2002

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

フィンガープリント 「<sup>11</sup>C-methionine uptake in cerebrovascular disease: A comparison with <sup>18</sup>F-FDG PET and <sup>99m</sup>Tc-HMPAO SPECT」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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