抄録
Three 125I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid were prepared by melt exchange procedures in isolated radiochemical yields of 12-60% after HPLC purification. Biodistribution studies in tumor-bearing mice showed very different in vivo tissue uptake properties from previous results obtained with 14C-labeled ascorbic acid and 6-deoxy-6-[18F]fluoro-L-ascorbic acid. None of these seems to be suitable radioiodinated analogs of L-ascorbic acid for imaging study of its in vivo biochemistry.
本文言語 | 英語 |
---|---|
ページ(範囲) | 737-750 |
ページ数 | 14 |
ジャーナル | Journal of Labelled Compounds and Radiopharmaceuticals |
巻 | 46 |
号 | 8 |
DOI | |
出版ステータス | 出版済み - 7月 2003 |
All Science Journal Classification (ASJC) codes
- 分析化学
- 生化学
- 放射線学、核医学およびイメージング
- 創薬
- 分光学
- 有機化学