125I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: Synthesis and preliminary tissue distribution

Fumihiko Yamamoto, Eri Kuwano, Tetsuo Kaneshiro, Shigeki Sasaki, Minoru Maeda

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)

抄録

Three 125I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid were prepared by melt exchange procedures in isolated radiochemical yields of 12-60% after HPLC purification. Biodistribution studies in tumor-bearing mice showed very different in vivo tissue uptake properties from previous results obtained with 14C-labeled ascorbic acid and 6-deoxy-6-[18F]fluoro-L-ascorbic acid. None of these seems to be suitable radioiodinated analogs of L-ascorbic acid for imaging study of its in vivo biochemistry.

本文言語英語
ページ(範囲)737-750
ページ数14
ジャーナルJournal of Labelled Compounds and Radiopharmaceuticals
46
8
DOI
出版ステータス出版済み - 7月 2003

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生化学
  • 放射線学、核医学およびイメージング
  • 創薬
  • 分光学
  • 有機化学

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