Supercritical fluid chromatography/mass spectrometry in metabolite analysis

Kaori Taguchi, Eiichiro Fukusaki, Takeshi Bamba

研究成果: Contribution to journalReview article査読

26 被引用数 (Scopus)

抄録

Supercritical fluid chromatography (SFC) owes many of its advantages to the properties of supercritical CO2, which possesses benefits as mobile phase. SFC has recently gained attention as a separation technique because it can be utilized for not only non-polar but also polar compound analysis. In addition, MS is widely adopted for SFC, and the options for MS are equivalent to liquid chromatography. Sensitive and selective detection is crucial in metabolite analysis. The SFC/MS system can be an alternative approach to liquid chromatography, as can metabolite analysis using packed-column SFC in biosamples. In this review we cover the fundamentals of SFC in combination with MS, and discuss the results of metabolite analysis using SFC/MS.

本文言語英語
ページ(範囲)1679-1689
ページ数11
ジャーナルBioanalysis
6
12
DOI
出版ステータス出版済み - 6 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 薬理学、毒性学および薬学(全般)
  • 臨床生化学
  • 医療検査技術

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