Suppression of atopic dermatitis in mice model by reducing inflammation utilizing phosphatidylserine-coated biodegradable microparticles

Purnima Kumar, Md Zahangir Hosain, Jeong Hun Kang, Masafumi Takeo, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Controlling inflammatory response is important to avoid chronic inflammation in many diseases including atopic dermatitis (AD). In this research, we tried using a phosphatidylserine (PS)-coated microparticles in the AD mouse model for achieving the modulation of the macrophage phenotype to an anti-inflammatory state. Here, we prepared poly (D,L-lactic acid) microparticle coated with PS on the outside shell. We confirmed the cellular uptake of the PS-coated microparticle, which leads to the significant downregulation of the inflammatory cytokine production. In the mouse model of AD, the PS-coated microparticle was injected subcutaneously for a period of 12 days. The mice showed significant reduction in the development of AD symptoms comparing with the mice treated with the PC-coated microparticle.

元の言語英語
ページ(範囲)1465-1474
ページ数10
ジャーナルJournal of Biomaterials Science, Polymer Edition
26
発行部数18
DOI
出版物ステータス出版済み - 12 12 2015

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Phosphatidylserines
Atopic Dermatitis
Inflammation
Macrophages
Lactic acid
Lactic Acid
Anti-Inflammatory Agents
Down-Regulation
Modulation
Cytokines
Phenotype
Research

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

これを引用

Suppression of atopic dermatitis in mice model by reducing inflammation utilizing phosphatidylserine-coated biodegradable microparticles. / Kumar, Purnima; Hosain, Md Zahangir; Kang, Jeong Hun; Takeo, Masafumi; Kishimura, Akihiro; Mori, Takeshi; Katayama, Yoshiki.

:: Journal of Biomaterials Science, Polymer Edition, 巻 26, 番号 18, 12.12.2015, p. 1465-1474.

研究成果: ジャーナルへの寄稿記事

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AU - Katayama, Yoshiki

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