Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Masumi Ikeda, Yuji Ishii, Harutoshi Kato, Daisuke Akazawa, Megumu Hatsumura, Takumi Ishida, Kimihiko Matsusue, Hideyuki Yamada, Kazuta Oguri

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

抄録

A coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl (PenCB), significantly suppresses the expression of rat liver carbonic anhydrase III (CAIII), an enzyme which has recently been suggested to prevent from H2O2-inducible apoptosis. Marked changes in the CAIII levels of liver cytosol were observed in rats following doses of PenCB ranging from 0.5 to 25 mg/kg body weight and maximum suppression was observed at a dose of 10 mg/kg. Northern analysis revealed that the level of CAIII mRNA in rat liver was dramatically reduced by PenCB treatment while only weak suppression was observed in pair-fed controls. Two AU-rich elements, considered as a destabilizing signal of mRNA, were found in the 3'-untranslated region of CAIII sequenced after reverse transcription-PCR and 3'-rapid amplification of the cDNA end. Dramatic decrease of CAIII in rat liver by PenCB could account for the suppression of the defense system for oxidative stress. (C) 2000 Academic Press.

元の言語英語
ページ(範囲)159-164
ページ数6
ジャーナルArchives of Biochemistry and Biophysics
380
発行部数1
DOI
出版物ステータス出版済み - 8 1 2000

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3,4,5,3',4'-pentachlorobiphenyl
Carbonic Anhydrase III
Dioxins
Poisons
Polychlorinated Biphenyls
Liver
Rats
AU Rich Elements
Messenger RNA
Oxidative stress
3' Untranslated Regions
Transcription
Cytosol
Reverse Transcription
Amplification
Oxidative Stress
Complementary DNA
Body Weight
Apoptosis
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology

これを引用

Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl. / Ikeda, Masumi; Ishii, Yuji; Kato, Harutoshi; Akazawa, Daisuke; Hatsumura, Megumu; Ishida, Takumi; Matsusue, Kimihiko; Yamada, Hideyuki; Oguri, Kazuta.

:: Archives of Biochemistry and Biophysics, 巻 380, 番号 1, 01.08.2000, p. 159-164.

研究成果: ジャーナルへの寄稿記事

Ikeda, Masumi ; Ishii, Yuji ; Kato, Harutoshi ; Akazawa, Daisuke ; Hatsumura, Megumu ; Ishida, Takumi ; Matsusue, Kimihiko ; Yamada, Hideyuki ; Oguri, Kazuta. / Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl. :: Archives of Biochemistry and Biophysics. 2000 ; 巻 380, 番号 1. pp. 159-164.
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abstract = "A coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl (PenCB), significantly suppresses the expression of rat liver carbonic anhydrase III (CAIII), an enzyme which has recently been suggested to prevent from H2O2-inducible apoptosis. Marked changes in the CAIII levels of liver cytosol were observed in rats following doses of PenCB ranging from 0.5 to 25 mg/kg body weight and maximum suppression was observed at a dose of 10 mg/kg. Northern analysis revealed that the level of CAIII mRNA in rat liver was dramatically reduced by PenCB treatment while only weak suppression was observed in pair-fed controls. Two AU-rich elements, considered as a destabilizing signal of mRNA, were found in the 3'-untranslated region of CAIII sequenced after reverse transcription-PCR and 3'-rapid amplification of the cDNA end. Dramatic decrease of CAIII in rat liver by PenCB could account for the suppression of the defense system for oxidative stress. (C) 2000 Academic Press.",
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