Suppression of host resistance against Listeria monocytogenes infection by 15-deoxyspergualin in mice

A. Nakane, A. Numata, T. Minagawa

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

The effects of 15-deoxyspergualin (DSG), an immunosupressive agent, on bost resistance against Listeria monocytogenes were studied in mice. Administration of DSG in the early phase of infection resulted in fatal listeriosis by preventing acquired anti-listerial resistance, even though the infectious dose was sublethal for the untreated controls. In contrast, DSG treatment started after development of the acquired immunity was ineffective. Endogenous production of interferon-gamma (IFN-γ) and tumour necrosis factor (TNF) in the bloodstreams induced by the infection was normal in DSG-treated mice. Nevertheless, augmentation of macrophage functions such as expression of major histocompatibility complex (MHC) class II antigens, phagocytic activity and listericidal activity induced by the infection was abrogated by DSG treatment. These results suggest that the inhibitory effect of DSG on antilisterial resistance might be different from cyclosporine A (CsA).

本文言語英語
ページ(範囲)560-565
ページ数6
ジャーナルImmunology
71
4
出版ステータス出版済み - 12 1 1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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