Suppression of immunoglobulin production in human peripheral blood mononuclear cells by monocytes via secretion of heavy-chain ferritin

Makiko Yamashita; Gakuro Harada; Shin ei Matsumoto; Yoshihiro Aiba; Akira Ichikawa; Tsukasa Fujiki; Miyako Udono; Shigeru Kabayama; Tadashi Yoshida; Pingbo Zhang; Hiroshi Fujii; Sanetaka Shirahata; Yoshinori Katakura

doi:10.1016/j.imbio.2013.08.011

Suppression of immunoglobulin production in human peripheral blood mononuclear cells by monocytes via secretion of heavy-chain ferritin

Makiko Yamashita, Gakuro Harada, Shin ei Matsumoto, Yoshihiro Aiba, Akira Ichikawa, Tsukasa Fujiki, Miyako Udono, Shigeru Kabayama, Tadashi Yoshida, Pingbo Zhang, Hiroshi Fujii, Sanetaka Shirahata, Yoshinori Katakura

システム生物工学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

8 被引用数 (Scopus)

抄録

In vitro antigen stimulation of peripheral blood mononuclear cells (PBMCs) does not induce immunoglobulin (Ig) production. However, pretreatment of PBMCs with l-leucyl-l-leucine methyl ester (LLME) prior to in vitro stimulation removes the suppression of Ig production. In the present study, we attempted to identify the target cells of LLME and determine the mechanisms by which Ig production in PBMCs is suppressed. We found that CD14⁺ monocytes are involved in the suppression of Ig production in PBMCs. Furthermore, we confirmed that heavy-chain ferritin derived from CD14⁺ monocytes suppresses Ig production in PBMCs, possibly through iron sequestration.

本文言語	英語
ページ（範囲）	149-157
ページ数	9
ジャーナル	Immunobiology
巻	219
号	2
DOI	https://doi.org/10.1016/j.imbio.2013.08.011
出版ステータス	出版済み - 2月 2014

!!!All Science Journal Classification (ASJC) codes

免疫アレルギー学
免疫学
血液学

文献へのアクセス

10.1016/j.imbio.2013.08.011

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「Suppression of immunoglobulin production in human peripheral blood mononuclear cells by monocytes via secretion of heavy-chain ferritin」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Yamashita, M., Harada, G., Matsumoto, S. E., Aiba, Y., Ichikawa, A., Fujiki, T., Udono, M., Kabayama, S., Yoshida, T., Zhang, P., Fujii, H., Shirahata, S., & Katakura, Y. (2014). Suppression of immunoglobulin production in human peripheral blood mononuclear cells by monocytes via secretion of heavy-chain ferritin. Immunobiology, 219(2), 149-157. https://doi.org/10.1016/j.imbio.2013.08.011

Yamashita, M, Harada, G, Matsumoto, SE, Aiba, Y, Ichikawa, A, Fujiki, T, Udono, M, Kabayama, S, Yoshida, T, Zhang, P, Fujii, H, Shirahata, S & Katakura, Y 2014, 'Suppression of immunoglobulin production in human peripheral blood mononuclear cells by monocytes via secretion of heavy-chain ferritin', Immunobiology, vol. 219, no. 2, pp. 149-157. https://doi.org/10.1016/j.imbio.2013.08.011

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abstract = "In vitro antigen stimulation of peripheral blood mononuclear cells (PBMCs) does not induce immunoglobulin (Ig) production. However, pretreatment of PBMCs with l-leucyl-l-leucine methyl ester (LLME) prior to in vitro stimulation removes the suppression of Ig production. In the present study, we attempted to identify the target cells of LLME and determine the mechanisms by which Ig production in PBMCs is suppressed. We found that CD14+ monocytes are involved in the suppression of Ig production in PBMCs. Furthermore, we confirmed that heavy-chain ferritin derived from CD14+ monocytes suppresses Ig production in PBMCs, possibly through iron sequestration.",

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AU - Ichikawa, Akira

AU - Fujiki, Tsukasa

AU - Udono, Miyako

AU - Kabayama, Shigeru

AU - Yoshida, Tadashi

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