Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expression

Ryuichi Murase, Tomoki Sumida, Rumi Kawamura, Akiko Onishi-Ishikawa, Hiroyuki Hamakawa, Sean D. McAllister, Pierre Yves Desprez

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

抜粋

Salivary gland cancer (SGC) represents the most common malignancy in the head and neck region, and often metastasizes to the lungs. The helix-loop-helix ID1 protein has been shown to control metastatic progression in many types of cancers. Using two different approaches to target the expression of ID1 (genetic knockdown and progesterone receptor introduction combined with progesterone treatment), we previously determined that the aggressiveness of salivary gland tumor ACCM cells in culture was suppressed. Here, using the same approaches to target ID1 expression, we investigated the ability of ACCM cells to generate lung metastatic foci in nude mice. Moreover, since both approaches would be challenging for applications in humans, we added a third approach, i.e., treatment of mice with a non-toxic cannabinoid compound known to down-regulate ID1 gene expression. All approaches aimed at targeting the pro-metastatic ID1 gene led to a significant reduction in the formation of lung metastatic foci. Therefore, targeting a key transcriptional regulator using different means results in the same reduction of the metastatic spread of SGC cells in animal models, suggesting a novel approach for the treatment of patients with aggressive SGC.

元の言語英語
ページ(範囲)11-16
ページ数6
ジャーナルCancer Letters
377
発行部数1
DOI
出版物ステータス出版済み - 7 10 2016

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Murase, R., Sumida, T., Kawamura, R., Onishi-Ishikawa, A., Hamakawa, H., McAllister, S. D., & Desprez, P. Y. (2016). Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expression. Cancer Letters, 377(1), 11-16. https://doi.org/10.1016/j.canlet.2016.04.021