Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus

Yupin Li, Takeki Hamasaki, Noboru Nakamichi, Taichi Kashiwagi, Takaaki Komatsu, Jun Ye, Kiichiro Teruya, Masumi Abe, Hanxu Yan, Tomoya Kinjo, Shigeru Kabayama, Munenori Kawamura, Sanetaka Shirahata

研究成果: ジャーナルへの寄稿学術誌査読

30 被引用数 (Scopus)

抄録

Electrolyzed reduced water, which is capable of scavenging reactive oxygen species, is attracting recent attention because it has shown improved efficacy against several types of diseases including diabetes mellitus. Alloxan produces reactive oxygen species and causes type 1 diabetes mellitus in experimental animals by irreversible oxidative damage to insulin-producing β-cells. Here, we showed that electrolyzed reduced water prevented alloxan-induced DNA fragmentation and the production of cells in sub-G1 phase in HIT-T15 pancreatic β-cells. Blood glucose levels in alloxan-induced type 1 diabetes model mice were also significantly suppressed by feeding the mice with electrolyzed reduced water. These results suggest that electrolyzed reduced water can prevent apoptosis of pancreatic β-cells and the development of symptoms in type 1 diabetes model mice by alleviating the alloxan-derived generation of reactive oxygen species.

本文言語英語
ページ(範囲)119-131
ページ数13
ジャーナルCytotechnology
63
2
DOI
出版ステータス出版済み - 3月 2011

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • バイオエンジニアリング
  • 生体医工学
  • 臨床生化学
  • 細胞生物学

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