Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity

Toshikatsu Hanada, Hiroki Yoshida, Seiya Kato, Kentaro Tanaka, Kosuke Masutani, Jun Tsukada, Yoshio Nomura, Hiromitsu Mimata, Masato Kubo, Akihiko Yoshimura

研究成果: ジャーナルへの寄稿記事

176 引用 (Scopus)

抄録

Suppressor of cytokine signaling-1 (SOCS1/JAB) negatively regulates not only the cytokine-signaling pathway but also lipopolysaccharide (LPS)-induced macrophage activation. We found that SOCS1-deficient dendritic cells (DCs) were also hyperresponsive to interferon-γ and interleukin-4. To define the role of SOCS1-deficient DCs in vivo, we generated mice in which the SOCS1 expression was restored in T and B cells on a SOCS1-/- background. In these mice, DCs were accumulated in the thymus and spleen and produced high levels of BAFF/BLyS and APRIL, resulting in the aberrant expansion of B cells and autoreactive antibody production. SOCS1-deficient DCs efficiently stimulated B cell proliferation in vitro and autoantibody production in vivo. These results indicate that SOCS1 plays an essential role in the normal DC functions and suppression of systemic autoimmunity.

元の言語英語
ページ(範囲)437-450
ページ数14
ジャーナルImmunity
19
発行部数3
DOI
出版物ステータス出版済み - 9 1 2003

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Autoimmunity
Dendritic Cells
Cytokines
B-Lymphocytes
Macrophage Activation
Interleukin-4
Autoantibodies
Thymus Gland
Interferons
Antibody Formation
Lipopolysaccharides
Spleen
Cell Proliferation
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

これを引用

Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. / Hanada, Toshikatsu; Yoshida, Hiroki; Kato, Seiya; Tanaka, Kentaro; Masutani, Kosuke; Tsukada, Jun; Nomura, Yoshio; Mimata, Hiromitsu; Kubo, Masato; Yoshimura, Akihiko.

:: Immunity, 巻 19, 番号 3, 01.09.2003, p. 437-450.

研究成果: ジャーナルへの寄稿記事

Hanada, T, Yoshida, H, Kato, S, Tanaka, K, Masutani, K, Tsukada, J, Nomura, Y, Mimata, H, Kubo, M & Yoshimura, A 2003, 'Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity', Immunity, 巻. 19, 番号 3, pp. 437-450. https://doi.org/10.1016/S1074-7613(03)00240-1
Hanada, Toshikatsu ; Yoshida, Hiroki ; Kato, Seiya ; Tanaka, Kentaro ; Masutani, Kosuke ; Tsukada, Jun ; Nomura, Yoshio ; Mimata, Hiromitsu ; Kubo, Masato ; Yoshimura, Akihiko. / Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. :: Immunity. 2003 ; 巻 19, 番号 3. pp. 437-450.
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abstract = "Suppressor of cytokine signaling-1 (SOCS1/JAB) negatively regulates not only the cytokine-signaling pathway but also lipopolysaccharide (LPS)-induced macrophage activation. We found that SOCS1-deficient dendritic cells (DCs) were also hyperresponsive to interferon-γ and interleukin-4. To define the role of SOCS1-deficient DCs in vivo, we generated mice in which the SOCS1 expression was restored in T and B cells on a SOCS1-/- background. In these mice, DCs were accumulated in the thymus and spleen and produced high levels of BAFF/BLyS and APRIL, resulting in the aberrant expansion of B cells and autoreactive antibody production. SOCS1-deficient DCs efficiently stimulated B cell proliferation in vitro and autoantibody production in vivo. These results indicate that SOCS1 plays an essential role in the normal DC functions and suppression of systemic autoimmunity.",
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AU - Masutani, Kosuke

AU - Tsukada, Jun

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AB - Suppressor of cytokine signaling-1 (SOCS1/JAB) negatively regulates not only the cytokine-signaling pathway but also lipopolysaccharide (LPS)-induced macrophage activation. We found that SOCS1-deficient dendritic cells (DCs) were also hyperresponsive to interferon-γ and interleukin-4. To define the role of SOCS1-deficient DCs in vivo, we generated mice in which the SOCS1 expression was restored in T and B cells on a SOCS1-/- background. In these mice, DCs were accumulated in the thymus and spleen and produced high levels of BAFF/BLyS and APRIL, resulting in the aberrant expansion of B cells and autoreactive antibody production. SOCS1-deficient DCs efficiently stimulated B cell proliferation in vitro and autoantibody production in vivo. These results indicate that SOCS1 plays an essential role in the normal DC functions and suppression of systemic autoimmunity.

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