Suppressor T cells control the HLA-linked low responsiveness to streptococcal antigen in man

Yasuharu Nishimura, Takehiko Sasazuki

研究成果: ジャーナルへの寄稿レター

43 引用 (Scopus)

抜粋

We have previously reported that low immune responsiveness to the streptococcal cell wall (SCW) antigen is controlled by an HLA -linked dominant gene which we designated as an immune suppression gene to the SCW antigen (Is-SCW) without knowing its function1. We have extended the study of the genetic control of the immune reponse to the SCW antigen and confirmed both the bimodal distribution of immune responsiveness and HLA-linked dominant inheritance of low responsiveness2. Here we report an analysis of the function and expression of Is-SCW at the cellular level and demonstrate that the Is-SCW controls the generation of antigen-specific suppressor T cell in low responders.

元の言語英語
ページ(範囲)67-69
ページ数3
ジャーナルNature
302
発行部数5903
DOI
出版物ステータス出版済み - 12 1 1983
外部発表Yes

All Science Journal Classification (ASJC) codes

  • General

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