Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: Regulation of T-cell inflammation by SOCS1 and SOCS3

Taiga Tamiya, Ikko Kashiwagi, Reiko Takahashi, Hideo Yasukawa, Akihiko Yoshimura

研究成果: Contribution to journalArticle査読

235 被引用数 (Scopus)

抄録

Various cytokines are involved in the regulation of the immune system and inflammation. Dysregulation of cytokine signaling can cause a variety of diseases, including allergy, autoimmune diseases, inflammation, and cancer. Most cytokines use the so-called janus kinase/signal transducer and activator of transcription pathway, and this pathway is negatively regulated by suppressors of cytokine signaling (SOCS) proteins. SOCS proteins bind to janus kinase and to certain cytokine receptors and signaling molecules, thereby suppressing further signaling events. Studies have shown that SOCS proteins are key physiological regulators of inflammation. Recent studies have also demonstrated that SOCS1 and SOCS3 are important regulators of adaptive immunity.

本文言語英語
ページ(範囲)980-985
ページ数6
ジャーナルArteriosclerosis, thrombosis, and vascular biology
31
5
DOI
出版ステータス出版済み - 5 2011

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

フィンガープリント

「Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: Regulation of T-cell inflammation by SOCS1 and SOCS3」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル