"Supramolecular" amphiphiles created by wrapping poly(styrene) with the helix-forming β-l,3-glucan polysaccharide

Munenori Numata, Kenji Kaneko, Hitoshi Tamiaki, Seiji Shinkai

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

We have demonstrated that giant polymer micelles with a uniform diameter (ca. 200 nm) can be fabricated by "supramolecular wrapping" of poly(styrene) (PS) with the β-1,3glucan polysaccharide, with the β-1,3glucan fastening the PS chains together in a noncovalent fashion to facilitate the formation of a supramolecular polymer network on the O/W emulsion surface. Various spectroscopic and microscopic investigations have revealed that the inner cores of the micelles are comprised of a hydrophobic PS net-work, whereas the surfaces consist of a hydrophilic β-l,3-glucan layer. Accordingly, functional guest molecules can easily be encapsulated inside the cavity through hydrophobic interactions. The encapsulated molecules can simply be released from the micelle cores by peeling off the β-l,3-glucan shell in a supramolecular manner. As functional groups can be introduced into the glucose side-chain unit in a straightforward manner by chemical modification, the micellar surface can acquire further functions useful for molecular recognition. These results show that the micelles obtained could have applications as novel soft nanoparticles, which would be indispensable not only for nanotechnologies, but also for biotechnologies aimed at gene or drug delivery systems.

元の言語英語
ページ(範囲)12338-12345
ページ数8
ジャーナルChemistry - A European Journal
15
発行部数45
DOI
出版物ステータス出版済み - 12 4 2009

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Amphiphiles
Styrene
Glucans
Micelles
Polysaccharides
Polymers
Molecular recognition
Molecules
Peeling
Chemical modification
Biotechnology
Emulsions
Nanotechnology
Functional groups
Glucose
Genes
Nanoparticles

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

これを引用

"Supramolecular" amphiphiles created by wrapping poly(styrene) with the helix-forming β-l,3-glucan polysaccharide. / Numata, Munenori; Kaneko, Kenji; Tamiaki, Hitoshi; Shinkai, Seiji.

:: Chemistry - A European Journal, 巻 15, 番号 45, 04.12.2009, p. 12338-12345.

研究成果: ジャーナルへの寄稿記事

Numata, Munenori ; Kaneko, Kenji ; Tamiaki, Hitoshi ; Shinkai, Seiji. / "Supramolecular" amphiphiles created by wrapping poly(styrene) with the helix-forming β-l,3-glucan polysaccharide. :: Chemistry - A European Journal. 2009 ; 巻 15, 番号 45. pp. 12338-12345.
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