抄録
Background. Cancer of the hypopharynx and cervical esophagus (PhCe cancer) frequently develops synchronously or metachronously with esophageal cancer. The surgical approach is usually difficult, especially in metachronous PhCe cancer after esophagectomy. The purpose of this study was to clarify the treatment outcomes of patients with metachronous PhCe cancer with a history of esophagectomy. Methods. The subjects evaluated in this study were 14 patients with metachronous PhCe cancer who underwent pharyngo-laryngo-esophagectomy after subtotal esophagectomy and gastric tube pull-up for primary esophageal cancer. Results. Definitive chemoradiotherapy (CRT; radiation dose >50 Gy) was performed for primary laryngeal (n = 1), pharyngeal (n = 2), esophageal (n = 1), and recurrent esophageal cancer (n = 2). For seven patients with metachronous PhCe cancer, induction CRT (radiation dose <40 Gy) was performed. In all 14 patients, pharyngo-laryngo-esophagectomy was followed by free jejunal graft interposition with reconstruction of the jejunal vessels. Although postoperative complications developed in four patients, no perioperative death or necrosis of the reconstructed free jejunum occurred. The 2- and 5-year overall survival rates were 84 and 50 %, respectively. Conclusions. Pharyngo-laryngo- esophagectomy with free jejunal transfer is considered to be safe for metachronous PhCe cancer, even in patients with a history of CRT and esophagectomy.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 1175-1181 |
| ページ数 | 7 |
| ジャーナル | Annals of Surgical Oncology |
| 巻 | 21 |
| 発行部数 | 4 |
| DOI | |
| 出版物ステータス | 出版済み - 4 2014 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oncology
これを引用
Surgical resection of hypopharynx and cervical esophageal cancer with a history of esophagectomy for thoracic esophageal cancer. / Ida, Satoshi; Morita, Masaru; Hiyoshi, Yukiharu; Ikeda, Keisuke; Ando, Koji; Kimura, Yasue; Saeki, Hiroshi; Oki, Eiji; Kusumoto, Tetsuya; Yoshida, Sei; Nakashima, Torahiko; Watanabe, Masayuki; Baba, Hideo; Maehara, Yoshihiko.
：: Annals of Surgical Oncology, 巻 21, 番号 4, 04.2014, p. 1175-1181.研究成果: ジャーナルへの寄稿 › 記事
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TY - JOUR
T1 - Surgical resection of hypopharynx and cervical esophageal cancer with a history of esophagectomy for thoracic esophageal cancer
AU - Ida, Satoshi
AU - Morita, Masaru
AU - Hiyoshi, Yukiharu
AU - Ikeda, Keisuke
AU - Ando, Koji
AU - Kimura, Yasue
AU - Saeki, Hiroshi
AU - Oki, Eiji
AU - Kusumoto, Tetsuya
AU - Yoshida, Sei
AU - Nakashima, Torahiko
AU - Watanabe, Masayuki
AU - Baba, Hideo
AU - Maehara, Yoshihiko
PY - 2014/4
Y1 - 2014/4
N2 - Background. Cancer of the hypopharynx and cervical esophagus (PhCe cancer) frequently develops synchronously or metachronously with esophageal cancer. The surgical approach is usually difficult, especially in metachronous PhCe cancer after esophagectomy. The purpose of this study was to clarify the treatment outcomes of patients with metachronous PhCe cancer with a history of esophagectomy. Methods. The subjects evaluated in this study were 14 patients with metachronous PhCe cancer who underwent pharyngo-laryngo-esophagectomy after subtotal esophagectomy and gastric tube pull-up for primary esophageal cancer. Results. Definitive chemoradiotherapy (CRT; radiation dose >50 Gy) was performed for primary laryngeal (n = 1), pharyngeal (n = 2), esophageal (n = 1), and recurrent esophageal cancer (n = 2). For seven patients with metachronous PhCe cancer, induction CRT (radiation dose <40 Gy) was performed. In all 14 patients, pharyngo-laryngo-esophagectomy was followed by free jejunal graft interposition with reconstruction of the jejunal vessels. Although postoperative complications developed in four patients, no perioperative death or necrosis of the reconstructed free jejunum occurred. The 2- and 5-year overall survival rates were 84 and 50 %, respectively. Conclusions. Pharyngo-laryngo- esophagectomy with free jejunal transfer is considered to be safe for metachronous PhCe cancer, even in patients with a history of CRT and esophagectomy.
AB - Background. Cancer of the hypopharynx and cervical esophagus (PhCe cancer) frequently develops synchronously or metachronously with esophageal cancer. The surgical approach is usually difficult, especially in metachronous PhCe cancer after esophagectomy. The purpose of this study was to clarify the treatment outcomes of patients with metachronous PhCe cancer with a history of esophagectomy. Methods. The subjects evaluated in this study were 14 patients with metachronous PhCe cancer who underwent pharyngo-laryngo-esophagectomy after subtotal esophagectomy and gastric tube pull-up for primary esophageal cancer. Results. Definitive chemoradiotherapy (CRT; radiation dose >50 Gy) was performed for primary laryngeal (n = 1), pharyngeal (n = 2), esophageal (n = 1), and recurrent esophageal cancer (n = 2). For seven patients with metachronous PhCe cancer, induction CRT (radiation dose <40 Gy) was performed. In all 14 patients, pharyngo-laryngo-esophagectomy was followed by free jejunal graft interposition with reconstruction of the jejunal vessels. Although postoperative complications developed in four patients, no perioperative death or necrosis of the reconstructed free jejunum occurred. The 2- and 5-year overall survival rates were 84 and 50 %, respectively. Conclusions. Pharyngo-laryngo- esophagectomy with free jejunal transfer is considered to be safe for metachronous PhCe cancer, even in patients with a history of CRT and esophagectomy.
UR - http://www.scopus.com/inward/record.url?scp=84896096180&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896096180&partnerID=8YFLogxK
U2 - 10.1245/s10434-013-3454-z
DO - 10.1245/s10434-013-3454-z
M3 - Article
C2 - 24380922
AN - SCOPUS:84896096180
VL - 21
SP - 1175
EP - 1181
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 4
ER -