Survival in synovial sarcoma: A multivariate study of prognostic factors with special emphasis on the comparison between early death and long-term survival

Y. Oda, H. Hashimoto, M. Tsuneyoshi, S. Takeshita

研究成果: ジャーナルへの寄稿学術誌査読

118 被引用数 (Scopus)

抄録

A retrospective study of 56 patients with synovial sarcoma was done to search for possible prognostic factors affecting survival. In a univariate analysis, age (≥20 years), site (proximal), large tumor size (≥5 cm), mitotic rate of more than 15 per 10 per high-power fields (hpf), high nuclear grade, tumor necrosis of more than 50%, the presence of rhabdoid cells, a small number of mast cells (<20/10 hpf), and a high stage according to the criteria of the American Joint Committee (AJC) staging of soft tissue sarcoma, significantly decreased survival (log-rank test; p < 0.05). Moreover, when comparing the 10-year survival (11 patients) and the deaths within 1 year (12 patients), size, high nuclear grade, presence of rhabdoid cells, tumor necrosis, and stage were all considered to be significant prognostic factors (two-sided chi-square test; p < 0.01). In a multivariate analysis (Cox's model), stage was the only strong predictor of a poor prognosis (p = 0.011). We therefore concluded that large tumor size, high nuclear grade, the presence of rhabdoid cells, extensive tumor necrosis, and a high AJC stage were adverse prognostic factors in synovial sarcoma.

本文言語英語
ページ(範囲)35-44
ページ数10
ジャーナルAmerican Journal of Surgical Pathology
17
1
DOI
出版ステータス出版済み - 1月 12 1993

!!!All Science Journal Classification (ASJC) codes

  • 解剖学
  • 外科
  • 病理学および法医学

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